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A deep learning model for structure-based bioactivity optimization and its application in the bioactivity optimization of a SARS-CoV-2 main protease inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 16
作者:  Yang, Zhenyu;  Wang, Kai;  Zhang, Guo;  Jiang, Yuanyuan;  Zeng, Rui;  Qiao, Jingxin;  Li, Yueyue;  Deng, Xinyue;  Xia, Ziyi;  Yao, Rui;  Zeng, Xiaoxi;  Zhang, Liyun;  Zhao, Yi;  Lei, Jian;  Chen, Runsheng
收藏  |  浏览/下载：7/0  |  提交时间：2025/06/25
Structure-based bioactivity optimization  Deep-learning model  SARS-CoV-2 main protease  Molecular scaffold  Pocket-StrMod  
AI Computing Systems for Large Language Models Training 期刊论文
JOURNAL OF COMPUTER SCIENCE AND TECHNOLOGY, 2025, 卷号: 40, 期号: 1, 页码: 6-41
作者:  Zhang, Zhen-Xing;  Wen, Yuan-Bo;  Lyu, Han-Qi;  Liu, Chang;  Zhang, Rui;  Li, Xia-Qing;  Wang, Chao;  Du, Zi-Dong;  Guo, Qi;  Li, Ling;  Zhou, Xue-Hai;  Chen, Yun-Ji
收藏  |  浏览/下载：6/0  |  提交时间：2025/06/25
artificial intelligence (AI) chip  large language model (LLM)  AI computing system  accelerator  
DeepFusion: A deep bimodal information fusion network for unraveling protein-RNA interactions using in vivo RNA structures 期刊论文
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2024, 卷号: 23, 页码: 617-625
作者:  Qiao, Yixuan;  Yang, Rui;  Liu, Yang;  Chen, Jiaxin;  Zhao, Lianhe;  Huo, Peipei;  Wang, Zhihao;  Bu, Dechao;  Wu, Yang;  Zhao, Yi
收藏  |  浏览/下载：37/0  |  提交时间：2024/05/20
Information fusion  Deep learning  RNA -binding proteins  In vivo RNA structures  Motifs  
Skyway: Accelerate Graph Applications with a Dual-Path Architecture and Fine-Grained Data Management 期刊论文
JOURNAL OF COMPUTER SCIENCE AND TECHNOLOGY, 2024, 卷号: 39, 期号: 4, 页码: 871-894
作者:  Zou, Mo;  Zhang, Ming-Zhe;  Wang, Ru-Jia;  Sun, Xian-He;  Ye, Xiao-Chun;  Fan, Dong-Rui;  Tang, Zhi-Min
收藏  |  浏览/下载：18/0  |  提交时间：2024/12/06
graph application  computer architecture  memory hierarchy  
TransSurv: Transformer-Based Survival Analysis Model Integrating Histopathological Images and Genomic Data for Colorectal Cancer 期刊论文
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2023, 卷号: 20, 期号: 6, 页码: 3411-3420
作者:  Lv, Zhilong;  Lin, Yuexiao;  Yan, Rui;  Wang, Ying;  Zhang, Fa
收藏  |  浏览/下载：60/0  |  提交时间：2024/05/20
Cancer  Genomics  Bioinformatics  Transformers  Tumors  Feature extraction  Prognostics and health management  Survival analysis  multi-modal learning  transformer  histopathological slides  genomic data  
FeCrypto: Instruction Set Architecture for Cryptographic Algorithms Based on FeFET-Based In-Memory Computing 期刊论文
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS, 2023, 卷号: 42, 期号: 9, 页码: 2889-2902
作者:  Liu, Rui;  Zhang, Xiaoyu;  Xie, Zhiwen;  Wang, Xinyu;  Li, Zerun;  Chen, Xiaoming;  Han, Yinhe;  Tang, Minghua
收藏  |  浏览/下载：37/0  |  提交时间：2023/12/04
Computing-in-memory (CiM)  cryptographic algorithm  ferroelectric field-effect transistor (FeFET)  instruc-tion set architecture (ISA)  
Toward a stable and low-resource PLM-based medical diagnostic system via prompt tuning and MoE structure 期刊论文
SCIENTIFIC REPORTS, 2023, 卷号: 13, 期号: 1, 页码: 15
作者:  Dong, Bowen;  Wang, Zhuo;  Li, Zhenyu;  Duan, Zhichao;  Xu, Jiacheng;  Pan, Tengyu;  Zhang, Rui;  Liu, Ning;  Li, Xiuxing;  Wang, Jie;  Liu, Caiyan;  Dong, Liling;  Mao, Chenhui;  Gao, Jing;  Wang, Jianyong
收藏  |  浏览/下载：43/0  |  提交时间：2023/12/04
Histopathological bladder cancer gene mutation prediction with hierarchical deep multiple-instance learning 期刊论文
MEDICAL IMAGE ANALYSIS, 2023, 卷号: 87, 页码: 13
作者:  Yan, Rui;  Shen, Yijun;  Zhang, Xueyuan;  Xu, Peihang;  Wang, Jun;  Li, Jintao;  Ren, Fei;  Ye, Dingwei;  Zhou, S. Kevin
收藏  |  浏览/下载：43/0  |  提交时间：2023/12/04
Bladder cancer  Contrastive learning  Gene mutation prediction  Histopathological image analysis  Multiple instance learning  
Biological knowledge graph-guided investigation of immune therapy response in cancer with graph neural network 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2023, 卷号: 24, 期号: 2, 页码: 9
作者:  Zhao, Lianhe;  Qi, Xiaoning;  Chen, Yang;  Qiao, Yixuan;  Bu, Dechao;  Wu, Yang;  Luo, Yufan;  Wang, Sheng;  Zhang, Rui;  Zhao, Yi
收藏  |  浏览/下载：29/0  |  提交时间：2023/12/04
immune checkpoints inhibitors  deep learning  graph neural networks  
香山开源高性能RISC-V处理器设计与实现 期刊论文
计算机研究与发展, 2023, 卷号: 60, 期号: 3, 页码: 476
作者:  王凯帆;  徐易难;  余子濠;  唐丹;  陈国凯;  陈熙;  勾凌睿;  胡轩;  金越;  李乾若;  李昕;  蔺嘉炜;  刘彤;  刘志刚;  王华强;  王诲喆;  张传奇;  张发旺;  张林隽;  张紫飞;  张梓悦;  赵阳洋;  周耀阳;  邹江瑞;  蔡晔;  郇丹丹;  李祖松;  赵继业;  何伟;  孙凝晖;  包云岗
收藏  |  浏览/下载：56/0  |  提交时间：2024/05/20
RISC-V  high performance processor  open source  chip design  agile development  RISC-V  高性能处理器  开源  芯片设计  敏捷开发