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A deep learning model for structure-based bioactivity optimization and its application in the bioactivity optimization of a SARS-CoV-2 main protease inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 16
作者:  Yang, Zhenyu;  Wang, Kai;  Zhang, Guo;  Jiang, Yuanyuan;  Zeng, Rui;  Qiao, Jingxin;  Li, Yueyue;  Deng, Xinyue;  Xia, Ziyi;  Yao, Rui;  Zeng, Xiaoxi;  Zhang, Liyun;  Zhao, Yi;  Lei, Jian;  Chen, Runsheng
收藏  |  浏览/下载：0/0  |  提交时间：2025/06/25
Structure-based bioactivity optimization  Deep-learning model  SARS-CoV-2 main protease  Molecular scaffold  Pocket-StrMod  
Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation 期刊论文
FRONTIERS IN MOLECULAR BIOSCIENCES, 2022, 卷号: 9, 页码: 23
作者:  Yang, Zhen;  Xu, Feng;  Teschendorff, Andrew E.;  Zhao, Yi;  Yao, Lei;  Li, Jian;  He, Yungang
收藏  |  浏览/下载：44/0  |  提交时间：2023/07/12
lncRNA  circRNA  DNA methylation  histone modification  transcriptional regulation  regulatory network  
BgNet: Classification of benign and malignant tumors with MRI multi-plane attention learning 期刊论文
FRONTIERS IN ONCOLOGY, 2022, 卷号: 12, 页码: 12
作者:  Liu, Hong;  Jiao, Meng-Lei;  Xing, Xiao-Ying;  Ou-Yang, Han-Qiang;  Yuan, Yuan;  Liu, Jian-Fang;  Li, Yuan;  Wang, Chun-Jie;  Lang, Ning;  Qian, Yue-Liang;  Jiang, Liang;  Yuan, Hui-Shu;  Wang, Xiang-Dong
收藏  |  浏览/下载：47/0  |  提交时间：2023/07/12
tumor classification  deep learning  multi-plane fusion  benign  malignant  
Femoral head segmentation based on improved fully convolutional neural network for ultrasound images 期刊论文
SIGNAL IMAGE AND VIDEO PROCESSING, 2020, 卷号: 14, 期号: 5, 页码: 1043-1051
作者:  Chen, Lei;  Cui, Yutao;  Song, Hong;  Huang, Bingxuan;  Yang, Jian;  Zhao, Di;  Xia, Bei
收藏  |  浏览/下载：69/0  |  提交时间：2020/12/10
Developmental dysplasia of the hip  Femoral head segmentation  Fully convolutional neural networks  Feature visualization  
Database Resources of the National Genomics Data Center in 2020 期刊论文
NUCLEIC ACIDS RESEARCH, 2020, 卷号: 48, 期号: D1, 页码: D24-D33
作者:  Zhang, Zhang;  Zhao, Wenming;  Xiao, Jingfa;  Bao, Yiming;  He, Shunmin;  Zhang, Guoqing;  Li, Yixue;  Zhao, Guoping;  Chen, Runsheng;  Gao, Yang;  Zhang, Chao;  Yuan, Liyun;  Xu, Shuhua;  Ning, Zhilin;  Lu, Yan;  Zeng, Jingyao;  Yuan, Na;  Zhu, Junwei;  Pan, Mengyu;  Zhang, Hao;  Wang, Qi;  Shi, Shuo;  Jiang, Meiye;  Lu, Mingming;  Qian, Qiheng;  Gao, Qianwen;  Shang, Yunfei;  Wang, Jinyue;  Du, Zhenglin;  Tian, Dongmei;  Wang, Pei;  Tang, Bixia;  Li, Cuiping;  Teng, Xufei;  Liu, Xiaonan;  Zou, Dong;  Song, Shuhui;  Xiong, Zhuang;  Li, Mengwei;  Yang, Fei;  Ma, Yingke;  Sang, Jian;  Li, Zhaohua;  Li, Rujiao;  Wang, Zhonghuang;  Zhu, Qianghui;  Li, Xin;  Zhang, Sisi;  Kang, Hailong;  Dong, Lili;  Ying, Cui;  Duan, Guangya;  Li, Menghua;  Zhi, Xiaoyang;  Ling, Yunchao;  Cao, Ruifang;  Jiang, Zhao;  Zhou, Haokui;  Lv, Daqing;  Liu, Wan;  Klenk, Hans-Peter;  Zhang, Yadong;  Zhang, Zhewen;  Chen, Tingting;  Chen, Xu;  Wang, Yanqing;  Wu, Song;  Gong, Zheng;  Chen, Meili;  Fang, Shuangsang;  Zhang, Lili;  Guo, Jincheng;  Niu, Yiwei;  Wu, Yang;  Li, Hui;  Zhao, Lianhe;  Li, Xiyuan;  Teng, Xueyi;  Sun, Xianhui;  Sun, Liang;  Zhao, Yi;  Wang, Jiajia;  Zhang, Peng;  Li, Yanyan;  Zheng, Yu;  Chen, Xiaomin;  Xue, Hua;  Teng, Yiheng;  Kang, Quan;  Hao, Yajing;  Cao, Jiabao;  Liu, Lin;  Li, Zhao;  Li, Qianpeng;  Du, Qiang;  Abbasi, Amir A.;  Shireen, Huma;  Pervaiz, Nashaiman;  Batool, Fatima;  Raza, Rabail Z.;  Ma, Lina;  Niu, Guangyi;  Zhang, Yuansheng;  Zhu, Tongtong;  Hao, Lili;  Wang, Guoliang;  Yan, Jun;  Li, Chen;  Wang, Zhennan;  Wang, Xiangfeng;  Li, Zhonghai;  Zhang, Yang;  Wang, Houling;  Zhang, Yi;  Xia, Xinli;  Guo, Hongwei;  Zhu, Junwen;  Zhou, Qing;  Kang, Hongen;  Lan, Li;  Zhang, Xin;  Xue, Yongbiao;  Sun, Yubin;  Zhai, Shuang;  Yu, Lei;  Sun, Mingyuan;  Chen, Huanxin;  Hu, Hui;  Guo, An-Yuan;  Lin, Shaofeng;  Xue, Yu;  Wang, Chenwei;  Ning, Wanshan;  Zhang, Xinxin;  Xiao, Yun;  Li, Xia;  Tu, Yiran;  Wu, Wanying;  Ji, Peifeng;  Zhao, Fangqing;  Luo, Hao;  Gao, Feng;  Guo, Yaping;  Yuan, Hao;  Zhang, Yong E.;  Zhang, Qiong;  Zhou, Jiaqi;  Huang, Zhou;  Cui, Qinghua;  Miao, Ya-Ru;  Ruan, Chen;  Yuan, Chunhui;  Chen, Ming;  Jin, Jin-Pu;  Tian, Feng;  Gao, Ge;  Shi, Ying;  Yao, Lan;  Li, Xiangshang;  Li, Chuan-Yun;  Tang, Qing;  Peng, Di
收藏  |  浏览/下载：131/0  |  提交时间：2020/12/10
HybridTune: Spatio-Temporal Performance Data Correlation for Performance Diagnosis of Big Data Systems 期刊论文
JOURNAL OF COMPUTER SCIENCE AND TECHNOLOGY, 2019, 卷号: 34, 期号: 6, 页码: 1167-1184
作者:  Ren, Rui;  Cheng, Jiechao;  He, Xi-Wen;  Wang, Lei;  Zhan, Jian-Feng;  Gao, Wan-Ling;  Luo, Chun-Jie
收藏  |  浏览/下载：61/0  |  提交时间：2020/12/10
Big Data system  spatio-temporal correlation  rule-based diagnosis  machine learning  
Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 11
作者:  Jones, Alexander X.;  Cao, Yong;  Tangi, Yu-Liang;  Wang, Jian-Hua;  Ding, Yue-He;  Tan, Hui;  Chen, Zhen-Lin;  Fang, Run-Qian;  Yin, Jili;  Chen, Rong-Chang;  Zhu, Xing;  She, Yang;  Huang, Niu;  Shao, Feng;  Ye, Keqiong;  Sun, Rui-Xiang;  He, Si-Min;  Lei, Xiaoguang;  Dong, Meng-Qiu
收藏  |  浏览/下载：118/0  |  提交时间：2019/12/10
Structure-Aware Local Sparse Coding for Visual Tracking 期刊论文
IEEE TRANSACTIONS ON IMAGE PROCESSING, 2018, 卷号: 27, 期号: 8, 页码: 3857-3869
作者:  Qi, Yuankai;  Qin, Lei;  Zhang, Jian;  Zhang, Shengping;  Huang, Qingming;  Yang, Ming-Hsuan
收藏  |  浏览/下载：88/0  |  提交时间：2019/12/10
Visual tracking  local sparse coding  spatial structure information  template update  
In-depth mapping of the mouse brain N-glycoproteome reveals widespread N-glycosylation of diverse brain proteins 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 25, 页码: 38796-38809
作者:  Fang, Pan;  Wang, Xin-jian;  Xue, Yu;  Liu, Ming-qi;  Zeng, Wen-feng;  Zhang, Yang;  Zhang, Lei;  Gao, Xing;  Yan, Guo-quan;  Yao, Jun;  Shen, Hua-li;  Yang, Peng-yuan
收藏  |  浏览/下载：79/0  |  提交时间：2019/12/13
N-glycoproteomics  mouse brain  mass spectrometry  brain physiological activities  disease biomarker  
BigDataBench：开源的大数据系统评测基准 期刊论文
计算机学报, 2016, 卷号: 39.0, 期号: 1.0, 页码: 196
作者:  詹剑锋;  高婉铃;  王磊;  李经伟;  魏凯;  罗纯杰;  韩锐;  田昕晖;  姜春宇
收藏  |  浏览/下载：31/0  |  提交时间：2023/12/04
大数据  基准测试  工业标准  测试方法  数据生成  应用案例