Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation

doi:10.3389/fmolb.2022.1067406

	Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation
	Yang, Zhen 1; Xu, Feng 1; Teschendorff, Andrew E.2; Zhao, Yi 3; Yao, Lei 4; Li, Jian 1; He, Yungang 1,5
	2022-12-02
发表期刊	FRONTIERS IN MOLECULAR BIOSCIENCES
卷号	9 页码:23
摘要	DNA methylation is one of the most important epigenetic mechanisms that governing regulation of gene expression, aberrant DNA methylation patterns are strongly associated with human malignancies. Long non-coding RNAs (lncRNAs) have being discovered as a significant regulator on gene expression at the epigenetic level. Emerging evidences have indicated the intricate regulatory effects between lncRNAs and DNA methylation. On one hand, transcription of lncRNAs are controlled by the promoter methylation, which is similar to protein coding genes, on the other hand, lncRNA could interact with enzymes involved in DNA methylation to affect the methylation pattern of downstream genes, thus regulating their expression. In addition, circular RNAs (circRNAs) being an important class of noncoding RNA are also found to participate in this complex regulatory network. In this review, we summarize recent research progress on this crosstalk between lncRNA, circRNA, and DNA methylation as well as their potential functions in complex diseases including cancer. This work reveals a hidden layer for gene transcriptional regulation and enhances our understanding for epigenetics regarding detailed mechanisms on lncRNA regulatory function in human cancers.
关键词	lncRNA circRNA DNA methylation histone modification transcriptional regulation regulatory network
DOI	10.3389/fmolb.2022.1067406
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China ; Shanghai Municipal Science and Technology ; Project of Science and Technology Department of Sichuan Provincial of China ; [91959106] ; [31871255] ; [2017SHZDZX01] ; [2019JDJQ0035]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000898774900001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/20220
专题	中国科学院计算技术研究所期刊论文
通讯作者	Yang, Zhen
作者单位	1.Fudan Univ, Pudong Hosp, Ctr Med Res & Innovat, Inst Biomed Sci,Shanghai Key Lab Med Epigenet,Int, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Computat Biol, Shanghai, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Beijing, Peoples R China 4.Southwest Med Univ, Affiliated Hosp, Expt Med Ctr, Luzhou, Sichuan, Peoples R China 5.Fudan Univ, Shanghai Peoples Hosp 5, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Yang, Zhen,Xu, Feng,Teschendorff, Andrew E.,et al. Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,9:23.
APA	Yang, Zhen.,Xu, Feng.,Teschendorff, Andrew E..,Zhao, Yi.,Yao, Lei.,...&He, Yungang.(2022).Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation.FRONTIERS IN MOLECULAR BIOSCIENCES,9,23.
MLA	Yang, Zhen,et al."Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation".FRONTIERS IN MOLECULAR BIOSCIENCES 9(2022):23.