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Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery 期刊论文
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 19
作者:  Qi, Xiaoning;  Zhao, Lianhe;  Tian, Chenyu;  Li, Yueyue;  Chen, Zhen-Lin;  Huo, Peipei;  Chen, Runsheng;  Liu, Xiaodong;  Wan, Baoping;  Yang, Shengyong;  Zhao, Yi
收藏  |  浏览/下载:2/0  |  提交时间:2024/12/06
Comparative Analysis of Chemical Cross-Linking Mass Spectrometry Data Indicates That Protein STY Residues Rarely React with N-Hydroxysuccinimide Ester Cross-Linkers 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2023, 卷号: 22, 期号: 8, 页码: 2593-2607
作者:  Cao, Yong;  Liu, Xin-Tong;  Mao, Peng-Zhi;  Chen, Zhen-Lin;  Tarn, Ching;  Dong, Meng-Qiu
收藏  |  浏览/下载:15/0  |  提交时间:2023/12/04
CXMS  XL-MS  NHS ester cross-linker  pLink  xiSearch  MeroX  
Recent Progress in Chemical Cross-linking Coupled With Mass Spectrometry 期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2022, 卷号: 49, 期号: 4, 页码: 737-758
作者:  Chen Zhen-Lin;  Cao Yong;  He Si-Min
收藏  |  浏览/下载:29/0  |  提交时间:2022/12/07
cross-linking mass spectrometry  protein structure  protein interaction  proteomics  mass spectrometry  
pDeepXL: MS/MS Spectrum Prediction for Cross-Linked Peptide Pairs by Deep Learning 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2021, 卷号: 20, 期号: 5, 页码: 2570-2582
作者:  Chen, Zhen-Lin;  Mao, Peng-Zhi;  Zeng, Wen-Feng;  Chi, Hao;  He, Si-Min
收藏  |  浏览/下载:48/0  |  提交时间:2021/12/01
cross-linking mass spectrometry  spectrum prediction  deep learning  transfer learning  online fine-tuning  
Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 11
作者:  Jones, Alexander X.;  Cao, Yong;  Tangi, Yu-Liang;  Wang, Jian-Hua;  Ding, Yue-He;  Tan, Hui;  Chen, Zhen-Lin;  Fang, Run-Qian;  Yin, Jili;  Chen, Rong-Chang;  Zhu, Xing;  She, Yang;  Huang, Niu;  Shao, Feng;  Ye, Keqiong;  Sun, Rui-Xiang;  He, Si-Min;  Lei, Xiaoguang;  Dong, Meng-Qiu
收藏  |  浏览/下载:102/0  |  提交时间:2019/12/10
A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 12
作者:  Chen, Zhen-Lin;  Meng, Jia-Ming;  Cao, Yong;  Yin, Ji-Li;  Fang, Run-Qian;  Fan, Sheng-Bo;  Liu, Chao;  Zeng, Wen-Feng;  Ding, Yue-He;  Tan, Dan;  Wu, Long;  Zhou, Wen-Jing;  Chi, Hao;  Sun, Rui-Xiang;  Dong, Meng-Qiu;  He, Si-Min
收藏  |  浏览/下载:102/0  |  提交时间:2019/12/10
Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine 期刊论文
NATURE BIOTECHNOLOGY, 2018, 卷号: 36, 期号: 11, 页码: 1059-+
作者:  Chi, Hao;  Liu, Chao;  Yang, Hao;  Zeng, Wen-Feng;  Wu, Long;  Zhou, Wen-Jing;  Wang, Rui-Min;  Niu, Xiu-Nan;  Ding, Yue-He;  Zhang, Yao;  Wang, Zhao-Wei;  Chen, Zhen-Lin;  Sun, Rui-Xiang;  Liu, Tao;  Tan, Guang-Ming;  Dong, Meng-Qiu;  Xu, Ping;  Zhang, Pei-Heng;  He, Si-Min
收藏  |  浏览/下载:95/0  |  提交时间:2019/08/16
pSite: Amino Acid Confidence Evaluation for Quality Control of De Novo Peptide Sequencing and Modification Site Localization 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2018, 卷号: 17, 期号: 1, 页码: 119-128
作者:  Yang, Hao;  Chi, Hao;  Zhou, Wen-Jing;  Zeng, Wen-Feng;  Liu, Chao;  Wang, Rui-Min;  Wang, Zhao-Wei;  Niu, Xiu-Nan;  Chen, Zhen-Lin;  He, Si-Min
收藏  |  浏览/下载:82/0  |  提交时间:2019/12/10
tandem mass spectrometry  de novo peptide sequencing  modification site localization  phosphorylation  
网络空间智慧搜索研究进展及关键科学问题 期刊论文
中国科学基金, 2015, 卷号: 29, 期号: 4, 页码: 256
作者:  方滨兴;  刘克;  吴曼青;  贾焰;  陈熙霖;  孟庆峰;  赵瑞珍;  张兆田;  秦玉文
收藏  |  浏览/下载:13/0  |  提交时间:2023/12/04
网络空间搜索  大搜索技术  意图理解  意图匹配  智慧解答  
结构化稀疏线性判别分析 期刊论文
计算机研究与发展, 2014, 卷号: 51.0, 期号: 010, 页码: 2295
作者:  崔振;  山世光;  陈熙霖
收藏  |  浏览/下载:11/0  |  提交时间:2023/12/04
线性判别分析  正交化  人脸识别  最小二乘  结构化稀疏