Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine

doi:10.1038/nbt.4236

	Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine
	Chi, Hao 1,2; Liu, Chao 1,2; Yang, Hao 1,2; Zeng, Wen-Feng 1,2; Wu, Long 1,2; Zhou, Wen-Jing 1,2; Wang, Rui-Min 1,2; Niu, Xiu-Nan 1,2; Ding, Yue-He 3; Zhang, Yao 4,5,6; Wang, Zhao-Wei 1,2; Chen, Zhen-Lin 1,2; Sun, Rui-Xiang 1,2; Liu, Tao 1; Tan, Guang-Ming 1; Dong, Meng-Qiu 3; Xu, Ping 4; Zhang, Pei-Heng 1; He, Si-Min 1,2
	2018-11-01
发表期刊	NATURE BIOTECHNOLOGY
ISSN	1087-0156
卷号	36 期号:11 页码:1059-+
摘要	We present a sequence-tag-based search engine, Open-pFind, to identify peptides in an ultra-large search space that includes coeluting peptides, unexpected modifications and digestions. Our method detects peptides with higher precision and speed than seven other search engines. Open-pFind identified 70-85% of the tandem mass spectra in four large-scale datasets and 14,064 proteins, each supported by at least two protein-unique peptides, in a human proteome dataset.
DOI	10.1038/nbt.4236
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2016YFA0501300] ; National Key Research and Development Program of China[2017YFA0505100] ; National Key Research and Development Program of China[2017YFC0906600] ; National Key Research and Development Program of China[2012CB316502] ; Youth Innovation Promotion Association CAS[2014091] ; National Natural Science Foundation of China[31470805] ; National Natural Science Foundation of China[31670834] ; National Natural Science Foundation of China[31700727] ; National Natural Science Foundation of China[21475141] ; CAS Interdisciplinary Innovation Team[Y604061000] ; International Collaboration Program[2014DFB30020] ; Beijing Training Project for The Leading Talents in ST[Z161100004916024]
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
WOS记录号	WOS:000450374000018
出版者	NATURE PUBLISHING GROUP
引用统计	被引频次：245[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/4336
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chi, Hao; He, Si-Min
作者单位	1.Chinese Acad Sci, Key Lab Intelligent Informat Proc, Inst Comp Technol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Natl Inst Biol Sci, Beijing, Peoples R China 4.Beijing Inst Life, Natl Ctr Prot Sci Beijing, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing, Peoples R China 5.Sun Yat Sen Univ, Coll Ecol & Evolut, State Key Lab Biocontrol, Guangzhou, Guangdong, Peoples R China 6.Sun Yat Sen Univ, Coll Ecol & Evolut, Guangdong Prov Key Lab Plant Resources, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Chi, Hao,Liu, Chao,Yang, Hao,et al. Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine[J]. NATURE BIOTECHNOLOGY,2018,36(11):1059-+.
APA	Chi, Hao.,Liu, Chao.,Yang, Hao.,Zeng, Wen-Feng.,Wu, Long.,...&He, Si-Min.(2018).Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine.NATURE BIOTECHNOLOGY,36(11),1059-+.
MLA	Chi, Hao,et al."Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine".NATURE BIOTECHNOLOGY 36.11(2018):1059-+.