中国科学院计算技术研究所机构知识库

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	The interplay between tissue-resident microbiome and host proteins by integrated multi-omics during progression of colorectal adenoma to carcinoma 期刊论文 IMETA, 2025, 页码: 37 作者:  Wu, Di;  Wang, An-Jun;  Bu, De-Chao;  Sun, Yan-Yan;  Li, Chen-Hao;  Hong, Yue-Mei;  Zhang, Shan;  Chen, Shi-Yang;  Zhou, Jin-An;  Zhang, Tian-Yi;  Yu, Min-Hao;  Ma, Yong-Jing;  Wang, Xiu-Li;  Xu, Jia;  He, Wei;  Heeschen, Christopher;  Chen, Jian-Feng;  Mao, Wen-Jun;  Ding, Hui;  Wu, Wen-Juan;  Zhao, Yi;  Wang, Hui;  Liu, Ning-Ning 收藏  |  浏览/下载：4/0  |  提交时间：2025/12/03 colorectal cancer  metagenomics  microbiota-host interaction  proteomics  tissue-resident microbiome
	LINS: A general medical Q&A framework for enhancing the quality and credibility of LLM-generated responses 期刊论文 NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 20 作者:  Wang, Sheng;  Zhao, Fangyuan;  Bu, Dechao;  Lu, Yunwei;  Gong, Ming;  Liu, Hongjie;  Yang, Zhaohui;  Zeng, Xiaoxi;  Yuan, Zhiyuan;  Wan, Baoping;  Sun, Jingbo;  Wu, Yang;  Zhao, Lianhe;  Wan, Xirun;  Huang, Wei;  Wang, Tao;  Xu, Mengtong;  Luo, Jianjun;  Liu, Jingjia;  Zheng, Jianjun;  Zhang, Wei;  Zhang, Kang;  Zhang, Hongjia;  Wang, Shu;  Chen, Runsheng;  Zhao, Yi 收藏  |  浏览/下载：5/0  |  提交时间：2025/12/03
	A deep learning model for structure-based bioactivity optimization and its application in the bioactivity optimization of a SARS-CoV-2 main protease inhibitor 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 16 作者:  Yang, Zhenyu;  Wang, Kai;  Zhang, Guo;  Jiang, Yuanyuan;  Zeng, Rui;  Qiao, Jingxin;  Li, Yueyue;  Deng, Xinyue;  Xia, Ziyi;  Yao, Rui;  Zeng, Xiaoxi;  Zhang, Liyun;  Zhao, Yi;  Lei, Jian;  Chen, Runsheng 收藏  |  浏览/下载：43/0  |  提交时间：2025/06/25 Structure-based bioactivity optimization  Deep-learning model  SARS-CoV-2 main protease  Molecular scaffold  Pocket-StrMod
	CIEC: Cross-tissue Immune Cell Type Enrichment and Expression Map Visualization for Cancer 期刊论文 GENOMICS PROTEOMICS & BIOINFORMATICS, 2025, 卷号: 23, 期号: 1, 页码: 8 作者:  He, Jinhua;  Luo, Haitao;  Wang, Wei;  Bu, Dechao;  Zou, Zhengkai;  Wang, Haolin;  Tang, Hongzhen;  Han, Zeping;  Luo, Wenfeng;  Shen, Jian;  Xie, Fangmei;  Zhao, Yi;  Xiang, Zhiming 收藏  |  浏览/下载：14/0  |  提交时间：2025/06/25 Cancer single-cell data  Cross-tissue analysis  Immune cell  Enrichment analysis  Expression map
	DeepFusion: A deep bimodal information fusion network for unraveling protein-RNA interactions using in vivo RNA structures 期刊论文 COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2024, 卷号: 23, 页码: 617-625 作者:  Qiao, Yixuan;  Yang, Rui;  Liu, Yang;  Chen, Jiaxin;  Zhao, Lianhe;  Huo, Peipei;  Wang, Zhihao;  Bu, Dechao;  Wu, Yang;  Zhao, Yi 收藏  |  浏览/下载：55/0  |  提交时间：2024/05/20 Information fusion  Deep learning  RNA -binding proteins  In vivo RNA structures  Motifs
	Enzyme Repertoires and Genomic Insights into Lycium barbarum Pectin Polysaccharide Biosynthesis 期刊论文 GENOMICS PROTEOMICS & BIOINFORMATICS, 2024, 卷号: 22, 期号: 6, 页码: 15 作者:  Yue, Haiyan;  Tang, Yiheng;  Li, Aixuan;  Zhang, Lili;  Niu, Yiwei;  Zhang, Yiming;  Wang, Hao;  Luo, Jianjun;  Zhao, Yi;  He, Shunmin;  Chen, Chang;  Chen, Runsheng 收藏  |  浏览/下载：39/0  |  提交时间：2025/06/25 Lycium barbarum  Lycium barbarum pectin polysaccharide  Phylogenetic expansion  lncRNA  Rhamnogalacturonan I rhamnosyltransferase
	HERB 2.0: an updated database integrating clinical and experimental evidence for traditional Chinese medicine 期刊论文 NUCLEIC ACIDS RESEARCH, 2024, 页码: 11 作者:  Gao, Kai;  Liu, Liu;  Lei, Shuangshuang;  Li, Zhinong;  Huo, Peipei;  Wang, Zhihao;  Dong, Lei;  Deng, Wenxin;  Bu, Dechao;  Zeng, Xiaoxi;  Li, Chun;  Zhao, Yi;  Zhang, Wei;  Wang, Wei;  Wu, Yang 收藏  |  浏览/下载：32/0  |  提交时间：2025/06/25
	Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery 期刊论文 NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 19 作者:  Qi, Xiaoning;  Zhao, Lianhe;  Tian, Chenyu;  Li, Yueyue;  Chen, Zhen-Lin;  Huo, Peipei;  Chen, Runsheng;  Liu, Xiaodong;  Wan, Baoping;  Yang, Shengyong;  Zhao, Yi 收藏  |  浏览/下载：39/0  |  提交时间：2024/12/06
	GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model 期刊论文 CELL RESEARCH, 2024, 页码: 16 作者:  Yang, Xiaodong;  Liu, Guole;  Feng, Guihai;  Bu, Dechao;  Wang, Pengfei;  Jiang, Jie;  Chen, Shubai;  Yang, Qinmeng;  Miao, Hefan;  Zhang, Yiyang;  Man, Zhenpeng;  Liang, Zhongming;  Wang, Zichen;  Li, Yaning;  Li, Zheng;  Liu, Yana;  Tian, Yao;  Liu, Wenhao;  Li, Cong;  Li, Ao;  Dong, Jingxi;  Hu, Zhilong;  Fang, Chen;  Cui, Lina;  Deng, Zixu;  Jiang, Haiping;  Cui, Wentao;  Zhang, Jiahao;  Yang, Zhaohui;  Li, Handong;  He, Xingjian;  Zhong, Liqun;  Zhou, Jiaheng;  Wang, Zijian;  Long, Qingqing;  Xu, Ping;  Wang, Hongmei;  Meng, Zhen;  Wang, Xuezhi;  Wang, Yangang;  Wang, Yong;  Zhang, Shihua;  Guo, Jingtao;  Zhao, Yi;  Zhou, Yuanchun;  Li, Fei;  Liu, Jing;  Chen, Yiqiang;  Yang, Ge;  Li, Xin 收藏  |  浏览/下载：43/0  |  提交时间：2024/12/06
	dbDEMC 3.0: Functional Exploration of Differentially Expressed miRNAs in Cancers of Human and Model Organisms (vol 20, pg 446, 2022) 期刊论文 GENOMICS PROTEOMICS & BIOINFORMATICS, 2024, 卷号: 22, 期号: 1, 页码: 1 作者:  Xu, Feng;  Wang, Yifan;  Ling, Yunchao;  Zhou, Chenfen;  Wang, Haizhou;  Teschendorff, Andrew E.;  Zhao, Yi;  Zhao, Haitao;  He, Yungang;  Zhang, Guoqing;  Yang, Zhen 收藏  |  浏览/下载：66/0  |  提交时间：2024/12/06