Institute of Computing Technology, Chinese Academy IR
| Chinese Immune Multi-Omics Atlas | |
| Yin, Jianhua1,2,3; Zheng, Yuhui4,5; Huang, Zhuoli4,5; Zhou, Wenwen4,5; Yuan, Yue4,6; Cai, Pengfei4,6; Bai, Yong1,7,8; Yang, Shichen4,5; Gao, Yue9; Duan, Shanshan5,10; Wang, Yang4,5; Xu, Zekai4,9; Zhang, Wenxi4,11; Zhang, Xinyu4,11; Wei, Yilin4,9; Huang, Yaling4,12,13; Liu, Ying4,5; Wang, Weikai4,5; Yang, Tao4; Zhang, Zhongjin5; Chen, Xiaoya5,10; Zhang, Xiru4,14; Lv, Jingzhi4,5; Li, Fupeng4,5; Zhang, Yan1; Zeng, Guodan4,5; Wang, Xue10; Ma, Wen4; Hou, Guixue15; Hao, Shijie6; Liu, Chang1,2,3; Lai, Yiwei1,2,3; Liu, Panhong4; Wang, Bo1,16; Li, Yuxiang17; Zhang, Wenwei1; Gao, Peng3,15; Xie, Jun3,18; Esteban, Miguel A.4,19; Gu, Ying1,20; Liu, Xin1,3,5; Ji, Jiansong21; Qi, Ting22,23; Liu, Boxiang24,25,26; Wang, Hua27,28; Zhao, Yi29; Yang, Xiao30,31; Wang, Xiangdong30,32; Chen, Runsheng33; Yang, Jian4,22,23; Yin, Ye15; Wang, Jian34; Cao, Yanan35; Xu, Xun1,3,5,7; Liu, Longqi3,5,6; Jin, Xin1,3,5,8,36; Liu, Chuanyu1,2,3,30 | |
| 2026-01-08 | |
| 发表期刊 | SCIENCE
 |
| ISSN | 0036-8075 |
| 卷号 | 391期号:6781页码:25 |
| 摘要 | Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), characterizing molecular variations linked to sex, age, and genetic variants through multi-omics analysis of more than 10 million circulating immune cells from 428 Chinese adults. CIMA established an enhancer-driven gene regulatory network comprising 237 robust regulons; identified 9600 eGenes and 52,361 caPeaks at cell type resolution; and revealed pleiotropic associations among immune-related disease risk loci, cis-expression quantitative trait loci (QTLs), and chromatin accessibility QTLs. Furthermore, the cell language model CIMA-CLM predicted chromatin accessibility and evaluated the effects of noncoding variants from chromatin sequences and gene expression. CIMA provides a comprehensive reference for immune-related disease research. |
| DOI | 10.1126/science.adt3130 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:001681996900004 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.204/handle/2XEOYT63/42800 |
| 专题 | 中国科学院计算技术研究所 |
| 通讯作者 | Cao, Yanan; Xu, Xun; Liu, Longqi; Jin, Xin; Liu, Chuanyu |
| 作者单位 | 1.BGI Res, State Key Lab Genome & Multiomics Technol, Shenzhen, Peoples R China 2.BGI Res, Shenzhen Proof Of Concept Ctr Digital Cytopathol, Shenzhen, Peoples R China 3.Shanxi Med Univ, BGI Collaborat Ctr Future Med, Taiyuan, Peoples R China 4.BGI Res, Shenzhen, Peoples R China 5.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 6.BGI Res, State Key Lab Genome & Multiomics Technol, Hangzhou, Peoples R China 7.Guangdong Prov Key Lab Genome Read & Write, Shenzhen, Peoples R China 8.BGI Res, Shenzhen Key Lab Trans Biotechnol, Shenzhen, Peoples R China 9.South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Peoples R China 10.BGI Res, Hangzhou, Peoples R China 11.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 12.BGI Res, Shenzhen Key Lab Single Cell Omics, Shenzhen, Peoples R China 13.Chinese Univ Hong Kong, Dept Surg, Hong Kong, Peoples R China 14.Northwest Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China 15.BGI, Shenzhen, Peoples R China 16.BGI Res, Shenzhen Key Lab Environm Microbial Genom & Applic, Shenzhen, Peoples R China 17.BGI Res, Wuhan, Peoples R China 18.Shanxi Med Univ, MOE Key Lab Coal Environm Pathogen & Prevent, Taiyuan, Peoples R China 19.BGI, 3DCStar lab, Shenzhen, Peoples R China 20.BGI Cell, Shenzhen, Peoples R China 21.Wenzhou Med Univ, Lishui Cent Hosp, Zhejiang Key Lab Imaging & Intervent Med, Dept Radiol,Affiliated Hosp 5, Lishui, Peoples R China 22.Westlake Lab Life Sci & Biomed, Hangzhou, Peoples R China 23.Westlake Univ, Sch Life Sci, Hangzhou, Peoples R China 24.Natl Univ Singapore, Fac Sci, Dept Pharm & Pharmaceut Sci, Singapore, Singapore 25.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biomed Informat, Singapore, Singapore 26.ASTAR, Genome Inst Singapore, Singapore, Singapore 27.Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei, Peoples R China 28.Anhui Med Univ, Key Lab Antiinflammatory & Immune Med, Minist Educ, Hefei, Peoples R China 29.Chinese Acad Sci, Inst Comp Technol, Beijing, Peoples R China 30.Fujian Med Univ, Zhangzhou Affiliated Hosp, Zhangzhou, Peoples R China 31.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ultrasound, Beijing, Peoples R China 32.Fudan Univ, Zhongshan Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China 33.Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing, Peoples R China 34.James D Watson Inst Genome Sci, Hangzhou, Peoples R China 35.Shanghai Jiao Tong Univ, Ruijin Hosp, Wuxi Branch, Ruijin Yangtze River Delta Hlth Inst,Sch Med, Shanghai, Peoples R China 36.South China Univ Technol, Sch Med, Guangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Jianhua,Zheng, Yuhui,Huang, Zhuoli,et al. Chinese Immune Multi-Omics Atlas[J]. SCIENCE,2026,391(6781):25. |
| APA | Yin, Jianhua.,Zheng, Yuhui.,Huang, Zhuoli.,Zhou, Wenwen.,Yuan, Yue.,...&Liu, Chuanyu.(2026).Chinese Immune Multi-Omics Atlas.SCIENCE,391(6781),25. |
| MLA | Yin, Jianhua,et al."Chinese Immune Multi-Omics Atlas".SCIENCE 391.6781(2026):25. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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