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Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery 期刊论文
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 19
作者:  Qi, Xiaoning;  Zhao, Lianhe;  Tian, Chenyu;  Li, Yueyue;  Chen, Zhen-Lin;  Huo, Peipei;  Chen, Runsheng;  Liu, Xiaodong;  Wan, Baoping;  Yang, Shengyong;  Zhao, Yi
收藏  |  浏览/下载：2/0  |  提交时间：2024/12/06
Determining protein structures in cellular lamella at pseudo-atomic resolution by GisSPA 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 9
作者:  Cheng, Jing;  Liu, Tong;  You, Xin;  Zhang, Fa;  Sui, Sen-Fang;  Wan, Xiaohua;  Zhang, Xinzheng
收藏  |  浏览/下载：18/0  |  提交时间：2023/12/04
VP-Detector: A 3D multi-scale dense convolutional neural network for macromolecule localization and classification in cryo-electron tomograms 期刊论文
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 2022, 卷号: 221, 页码: 14
作者:  Hao, Yu;  Wan, Xiaohua;  Yan, Rui;  Liu, Zhiyong;  Li, Jintao;  Zhang, Shihua;  Cui, Xuefeng;  Zhang, Fa
收藏  |  浏览/下载：20/0  |  提交时间：2023/07/12
Cryo-ET  Sub-tomogram averaging  Particle localization  Particle classification  Convolutional neural networks  
Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 11
作者:  Wan, Jiang-fan;  Wang, Gang;  Qin, Fu-ying;  Huang, Dan-ling;  Wang, Yan;  Su, Ai-ling;  Zhang, Hai-ping;  Liu, Yang;  Zeng, Shao-yin;  Wei, Chao-liang;  Cheng, Yong-xian;  Liu, Jie
收藏  |  浏览/下载：36/0  |  提交时间：2022/12/07
arrhythmia  catecholaminergic polymorphic ventricular tachycardia  natural product  ryanodine receptor  induced pluripotent stem cell-derived cardiomyocytes  
Multi-labelled proteins recognition for high-throughput microscopy images using deep convolutional neural networks 期刊论文
BMC BIOINFORMATICS, 2021, 卷号: 22, 期号: SUPPL 3, 页码: 14
作者:  Zhang, Enze;  Zhang, Boheng;  Hu, Shaohan;  Zhang, Fa;  Liu, Zhiyong;  Wan, Xiaohua
收藏  |  浏览/下载：47/0  |  提交时间：2021/12/01
Protein pattern recognition  DNNs  Multi-class and multi-label  Label imbalance  High-throughput microscopy images  
A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro 期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2020, 卷号: 16, 期号: 12, 页码: 20
作者:  Zhang, Haiping;  Yang, Yang;  Li, Junxin;  Wang, Min;  Saravanan, Konda Mani;  Wei, Jinli;  Ng, Justin Tze-Yang;  Hossain, Md Tofazzal;  Liu, Maoxuan;  Zhang, Huiling;  Ren, Xiaohu;  Pan, Yi;  Peng, Yin;  Shi, Yi;  Wan, Xiaochun;  Liu, Yingxia;  Wei, Yanjie
收藏  |  浏览/下载：48/0  |  提交时间：2021/12/01
A Parallel Cerebrovascular Segmentation Algorithm Based on Focused Multi-Gaussians Model and Heterogeneous Markov Random Field 期刊论文
IEEE TRANSACTIONS ON NANOBIOSCIENCE, 2020, 卷号: 19, 期号: 3, 页码: 538-546
作者:  Lv, Zhilong;  Mi, Fubo;  Wu, Zhongke;  Zhu, Yicheng;  Liu, Xinyu;  Tian, Mei;  Zhang, Fa;  Wang, Xingce;  Wan, Xiaohua
收藏  |  浏览/下载：64/0  |  提交时间：2020/12/10
Gaussian distribution  Image segmentation  Particle swarm optimization  Optimization  Histograms  Markov random fields  Robustness  Three-dimensional cerebrovascular segmentation  focused multi-Gaussians model  Chaotic oscillation particle swarm optimization  Markov random field  
Optimizing TCP Loss Recovery Performance Over Mobile Data Networks 期刊论文
IEEE TRANSACTIONS ON MOBILE COMPUTING, 2020, 卷号: 19, 期号: 6, 页码: 1401-1419
作者:  Liu, Ke;  Zha, Zhongbin;  Wan, Wenkai;  Aggarwal, Vaneet;  Fu, Binzhang;  Chen, Mingyu
收藏  |  浏览/下载：54/0  |  提交时间：2020/12/10
Throughput  Bandwidth  Microsoft Windows  Linux  Kernel  Degradation  Packet loss  TCP  loss recovery  mobile data network  opportunistic retransmission  application stall  
Database Resources of the National Genomics Data Center in 2020 期刊论文
NUCLEIC ACIDS RESEARCH, 2020, 卷号: 48, 期号: D1, 页码: D24-D33
作者:  Zhang, Zhang;  Zhao, Wenming;  Xiao, Jingfa;  Bao, Yiming;  He, Shunmin;  Zhang, Guoqing;  Li, Yixue;  Zhao, Guoping;  Chen, Runsheng;  Gao, Yang;  Zhang, Chao;  Yuan, Liyun;  Xu, Shuhua;  Ning, Zhilin;  Lu, Yan;  Zeng, Jingyao;  Yuan, Na;  Zhu, Junwei;  Pan, Mengyu;  Zhang, Hao;  Wang, Qi;  Shi, Shuo;  Jiang, Meiye;  Lu, Mingming;  Qian, Qiheng;  Gao, Qianwen;  Shang, Yunfei;  Wang, Jinyue;  Du, Zhenglin;  Tian, Dongmei;  Wang, Pei;  Tang, Bixia;  Li, Cuiping;  Teng, Xufei;  Liu, Xiaonan;  Zou, Dong;  Song, Shuhui;  Xiong, Zhuang;  Li, Mengwei;  Yang, Fei;  Ma, Yingke;  Sang, Jian;  Li, Zhaohua;  Li, Rujiao;  Wang, Zhonghuang;  Zhu, Qianghui;  Li, Xin;  Zhang, Sisi;  Kang, Hailong;  Dong, Lili;  Ying, Cui;  Duan, Guangya;  Li, Menghua;  Zhi, Xiaoyang;  Ling, Yunchao;  Cao, Ruifang;  Jiang, Zhao;  Zhou, Haokui;  Lv, Daqing;  Liu, Wan;  Klenk, Hans-Peter;  Zhang, Yadong;  Zhang, Zhewen;  Chen, Tingting;  Chen, Xu;  Wang, Yanqing;  Wu, Song;  Gong, Zheng;  Chen, Meili;  Fang, Shuangsang;  Zhang, Lili;  Guo, Jincheng;  Niu, Yiwei;  Wu, Yang;  Li, Hui;  Zhao, Lianhe;  Li, Xiyuan;  Teng, Xueyi;  Sun, Xianhui;  Sun, Liang;  Zhao, Yi;  Wang, Jiajia;  Zhang, Peng;  Li, Yanyan;  Zheng, Yu;  Chen, Xiaomin;  Xue, Hua;  Teng, Yiheng;  Kang, Quan;  Hao, Yajing;  Cao, Jiabao;  Liu, Lin;  Li, Zhao;  Li, Qianpeng;  Du, Qiang;  Abbasi, Amir A.;  Shireen, Huma;  Pervaiz, Nashaiman;  Batool, Fatima;  Raza, Rabail Z.;  Ma, Lina;  Niu, Guangyi;  Zhang, Yuansheng;  Zhu, Tongtong;  Hao, Lili;  Wang, Guoliang;  Yan, Jun;  Li, Chen;  Wang, Zhennan;  Wang, Xiangfeng;  Li, Zhonghai;  Zhang, Yang;  Wang, Houling;  Zhang, Yi;  Xia, Xinli;  Guo, Hongwei;  Zhu, Junwen;  Zhou, Qing;  Kang, Hongen;  Lan, Li;  Zhang, Xin;  Xue, Yongbiao;  Sun, Yubin;  Zhai, Shuang;  Yu, Lei;  Sun, Mingyuan;  Chen, Huanxin;  Hu, Hui;  Guo, An-Yuan;  Lin, Shaofeng;  Xue, Yu;  Wang, Chenwei;  Ning, Wanshan;  Zhang, Xinxin;  Xiao, Yun;  Li, Xia;  Tu, Yiran;  Wu, Wanying;  Ji, Peifeng;  Zhao, Fangqing;  Luo, Hao;  Gao, Feng;  Guo, Yaping;  Yuan, Hao;  Zhang, Yong E.;  Zhang, Qiong;  Zhou, Jiaqi;  Huang, Zhou;  Cui, Qinghua;  Miao, Ya-Ru;  Ruan, Chen;  Yuan, Chunhui;  Chen, Ming;  Jin, Jin-Pu;  Tian, Feng;  Gao, Ge;  Shi, Ying;  Yao, Lan;  Li, Xiangshang;  Li, Chuan-Yun;  Tang, Qing;  Peng, Di
收藏  |  浏览/下载：111/0  |  提交时间：2020/12/10
A Consensus Framework of Distributed Multiple-Tilt Reconstruction in Electron Tomography 期刊论文
JOURNAL OF COMPUTATIONAL BIOLOGY, 2019, 页码: 11
作者:  Wang, Zihao;  Zhang, Jingrong;  Gao, Weifang;  Liu, Zhiyong;  Wan, Xiaohua;  Zhang, Fa
收藏  |  浏览/下载：51/0  |  提交时间：2020/12/10
consensus optimization  cryoelectron tomography  multiple-tilt reconstruction  parallel computing  TxBR