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The interplay between tissue-resident microbiome and host proteins by integrated multi-omics during progression of colorectal adenoma to carcinoma 期刊论文
IMETA, 2025, 页码: 37
作者:  Wu, Di;  Wang, An-Jun;  Bu, De-Chao;  Sun, Yan-Yan;  Li, Chen-Hao;  Hong, Yue-Mei;  Zhang, Shan;  Chen, Shi-Yang;  Zhou, Jin-An;  Zhang, Tian-Yi;  Yu, Min-Hao;  Ma, Yong-Jing;  Wang, Xiu-Li;  Xu, Jia;  He, Wei;  Heeschen, Christopher;  Chen, Jian-Feng;  Mao, Wen-Jun;  Ding, Hui;  Wu, Wen-Juan;  Zhao, Yi;  Wang, Hui;  Liu, Ning-Ning
收藏  |  浏览/下载：3/0  |  提交时间：2025/12/03
colorectal cancer  metagenomics  microbiota-host interaction  proteomics  tissue-resident microbiome  
A deep learning model for structure-based bioactivity optimization and its application in the bioactivity optimization of a SARS-CoV-2 main protease inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 16
作者:  Yang, Zhenyu;  Wang, Kai;  Zhang, Guo;  Jiang, Yuanyuan;  Zeng, Rui;  Qiao, Jingxin;  Li, Yueyue;  Deng, Xinyue;  Xia, Ziyi;  Yao, Rui;  Zeng, Xiaoxi;  Zhang, Liyun;  Zhao, Yi;  Lei, Jian;  Chen, Runsheng
收藏  |  浏览/下载：36/0  |  提交时间：2025/06/25
Structure-based bioactivity optimization  Deep-learning model  SARS-CoV-2 main protease  Molecular scaffold  Pocket-StrMod  
Global Analysis of Protein and Small-Molecule Substrates of Ubiquitin-Like Proteins 期刊论文
MOLECULAR & CELLULAR PROTEOMICS, 2025, 卷号: 24, 期号: 7, 页码: 20
作者:  Shao, Guang-Can;  Chen, Zhen-Lin;  Lu, Shan;  Wu, Qing-Cui;  Sheng, Yao;  Wang, Jing;  Ma, Yan;  Sui, Jian-Hua;  Chi, Hao;  Qi, Xiang-Bing;  He, Si-Min;  Du, Li-Lin;  Dong, Meng-Qiu
收藏  |  浏览/下载：2/0  |  提交时间：2025/12/03
XiangShan: An Open Source Project for High-Performance RISC-V Processors Meeting Industrial-Grade Standards 期刊论文
IEEE MICRO, 2025, 卷号: 45, 期号: 3, 页码: 49-57
作者:  Wang, Kaifan;  Chen, Jian;  Xu, Yinan;  Yu, Zihao;  He, Wei;  Tang, Dan;  Sun, Ninghui;  Bao, Yungang
收藏  |  浏览/下载：0/0  |  提交时间：2025/12/03
Program processors  Vectors  Technological innovation  Pipelines  Microarchitecture  Ecosystems  Decoding  Training  Registers  Industries  
Multitask-Based Self-Supervised Learning for Recommendation in Social Systems 期刊论文
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS, 2024, 页码: 12
作者:  Xu, Wenjian;  Zeng, Fanxiang;  Zhang, Nan;  Gao, Honghao;  Yin, Yuyu;  Chen, Zulong;  Huang, Maolei;  Wan, Jian
收藏  |  浏览/下载：33/0  |  提交时间：2025/06/25
Data models  Predictive models  Heavily-tailed distribution  Feature extraction  Representation learning  Recommender systems  Electronic mail  Computational modeling  Poles and towers  Data mining  Click-through rate (CTR) prediction  large-scale knowledge discovery  multitask learning  representation learning  user behavior modeling  
DPA-2: a large atomic model as a multi-task learner 期刊论文
NPJ COMPUTATIONAL MATERIALS, 2024, 卷号: 10, 期号: 1, 页码: 15
作者:  Zhang, Duo;  Liu, Xinzijian;  Zhang, Xiangyu;  Zhang, Chengqian;  Cai, Chun;  Bi, Hangrui;  Du, Yiming;  Qin, Xuejian;  Peng, Anyang;  Huang, Jiameng;  Li, Bowen;  Shan, Yifan;  Zeng, Jinzhe;  Zhang, Yuzhi;  Liu, Siyuan;  Li, Yifan;  Chang, Junhan;  Wang, Xinyan;  Zhou, Shuo;  Liu, Jianchuan;  Luo, Xiaoshan;  Wang, Zhenyu;  Jiang, Wanrun;  Wu, Jing;  Yang, Yudi;  Yang, Jiyuan;  Yang, Manyi;  Gong, Fu-Qiang;  Zhang, Linshuang;  Shi, Mengchao;  Dai, Fu-Zhi;  York, Darrin M.;  Liu, Shi;  Zhu, Tong;  Zhong, Zhicheng;  Lv, Jian;  Cheng, Jun;  Jia, Weile;  Chen, Mohan;  Ke, Guolin;  Weinan, E.;  Zhang, Linfeng;  Wang, Han
收藏  |  浏览/下载：40/0  |  提交时间：2025/06/25
A retrospective study on the mechanism underlying quick transfer from response to resistance in a repeated recurrent chordoma patient with molecular alterations treated with Palbociclib 期刊论文
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2024, 卷号: 150, 期号: 2, 页码: 9
作者:  Zhong, Nanzhe;  Yu, Dong;  Yang, Minglei;  Lu, Xingyi;  Zhang, Qiangzu;  Wei, Wei;  Jiao, Jian;  Yang, Xinghai;  Zhu, Zhi;  Chen, Su;  Xiao, Jianru
收藏  |  浏览/下载：92/0  |  提交时间：2024/05/20
Chordoma  Palbociclib  Genomic features  Drug resistance  
面向多阶段匹配的答案选择模型 期刊论文
计算机工程与应用, 2023, 卷号: 59, 期号: 3, 页码: 158
作者:  陈建贵;  张儒清;  郭嘉丰;  范意兴
收藏  |  浏览/下载：46/0  |  提交时间：2024/05/20
answer selection  question answering  knowledge enhancement  答案选择  问答系统  知识增强  
Scalable algorithm simplification using quantum AND logic 期刊论文
NATURE PHYSICS, 2022, 页码: 7
作者:  Chu, Ji;  He, Xiaoyu;  Zhou, Yuxuan;  Yuan, Jiahao;  Zhang, Libo;  Guo, Qihao;  Hai, Yongju;  Han, Zhikun;  Hu, Chang-Kang;  Huang, Wenhui;  Jia, Hao;  Jiao, Dawei;  Li, Sai;  Liu, Yang;  Ni, Zhongchu;  Nie, Lifu;  Pan, Xianchuang;  Qiu, Jiawei;  Wei, Weiwei;  Nuerbolati, Wuerkaixi;  Yang, Zusheng;  Zhang, Jiajian;  Zhang, Zhida;  Zou, Wanjing;  Chen, Yuanzhen;  Deng, Xiaowei;  Deng, Xiuhao;  Hu, Ling;  Li, Jian;  Liu, Song;  Lu, Yao;  Niu, Jingjing;  Tan, Dian;  Xu, Yuan;  Yan, Tongxing;  Zhong, Youpeng;  Yan, Fei;  Sun, Xiaoming;  Yu, Dapeng
收藏  |  浏览/下载：58/0  |  提交时间：2023/07/12
A New Feature Based Deep Attention Sales Forecasting Model for Enterprise Sustainable Development 期刊论文
SUSTAINABILITY, 2022, 卷号: 14, 期号: 19, 页码: 18
作者:  Huang, Jian;  Chen, Qinyu;  Yu, Chengqing
收藏  |  浏览/下载：51/0  |  提交时间：2023/07/12
enterprise sustainable development  E-commerce  sales forecasting  feature engineering  deep learning  attention mechanism