Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma

	Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma
	Zhang, Haohai 1,2; Zhu, Chengpei 1,2; Zhao, Yi 3,4; Li, Ming 5; Wu, Liangcai 1,2; Yang, Xiaobo 1,2; Wan, Xueshuai 1,2; Wang, Anqiang 1,2; Zhang, Michael Q.1,2,3,4; Sang, Xinting 1,2; Zhao, Haitao 1,2
	2015-12-22
发表期刊	ONCOTARGET
ISSN	1949-2553
卷号	6 期号:41 页码:43770-43778
摘要	Recently, long non-coding RNAs (IncRNAs) were found to be implicated in cancer progression. However, the contributions of IncRNAs to Hepatitis C virus-related hepatocellular carcinoma (HCC) remain largely unknown. Here, we characterized IncRNA expression in 73 tissue samples from several different developmental stages of HCV-related hepatocarcinogenesis by repurposing microarray data sets. We found that the expression of 7 IncRNAs in preneoplastic lesions and HCC was significantly different. Among these significantly differently expressed IncRNAs, the IncRNA LINC01419 transcripts were expressed at higher levels in early stage HCC compared to dysplasia and as compared with early stage HCC, IncRNA AK021443 level increase in advanced stage HCC while IncRNA AF070632 level decrease in advanced stage HCC. Using quantitative real-time reverse-transcription PCR, we validated that LINC01419 was significantly overexpressed in HBV-related and HCV-related HCC when compared with matched non-tumor liver tissues. Moreover, functional predictions suggested that LINC01419 and AK021443 regulate cell cycle genes, whereas AF070632 is associated with cofactor binding, oxidation-reduction and carboxylic acid catabolic process. These findings provide the first large-scale survey of IncRNAs associated with the development of hepatocarcinogenesis and may offer new diagnostic biomarkers and therapeutic targets for HCV-related HCC.
关键词	long non-coding RNAs hepatitis C virus-refafed HCC hepafocarcinogenfc process biomarkers
收录类别	SCI
语种	英语
资助项目	International Science and Technology Cooperation Projects[2015DFA30650] ; International Science and Technology Cooperation Projects[2010DFB33720] ; Capital Special Research Project for Health Development[2014-2-4012] ; Capital Research Project for the Characteristics Clinical application[Z151100004015170] ; Program for New Program for New Century Excellent Talents in University[NCET-11-0288]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000369908400045
出版者	IMPACT JOURNALS LLC
引用统计	被引频次：62[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/8723
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhao, Haitao
作者单位	1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Liver Surg, Beijing 100730, Peoples R China 2.Peking Union Med Coll, Beijing 100021, Peoples R China 3.Tsinghua Univ, Sch Med, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China 4.Tsinghua Univ, Ctr Synthet & Syst Biol, Bioinformat Div, Beijing 100084, Peoples R China 5.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Haohai,Zhu, Chengpei,Zhao, Yi,et al. Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma[J]. ONCOTARGET,2015,6(41):43770-43778.
APA	Zhang, Haohai.,Zhu, Chengpei.,Zhao, Yi.,Li, Ming.,Wu, Liangcai.,...&Zhao, Haitao.(2015).Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma.ONCOTARGET,6(41),43770-43778.
MLA	Zhang, Haohai,et al."Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma".ONCOTARGET 6.41(2015):43770-43778.