ICON: 3D reconstruction with 'missing-information' restoration in biological electron tomography

doi:10.1016/j.jsb.2016.04.004

	ICON: 3D reconstruction with 'missing-information' restoration in biological electron tomography
	Deng, Yuchen 1,4; Chen, Yu 2,4; Zhang, Yan 1; Wang, Shengliu 1,4; Zhang, Fa 2; Sun, Fei 1,3,4
	2016-07-01
发表期刊	JOURNAL OF STRUCTURAL BIOLOGY
ISSN	1047-8477
卷号	195 期号:1 页码:100-112
摘要	Electron tomography (ET) plays an important role in revealing biological structures, ranging from macro molecular to subcellular scale. Due to limited tilt angles, ET reconstruction always suffers from the 'missing wedge' artifacts, thus severely weakens the further biological interpretation. In this work, we developed an algorithm called Iterative Compressed-sensing Optimized Non-uniform fast Fourier transform reconstruction (ICON) based on the theory of compressed-sensing and the assumption of sparsity of biological specimens. ICON can significantly restore the missing information in comparison with other reconstruction algorithms. More importantly, we used the leave-one-out method to verify the validity of restored information for both simulated and experimental data. The significant improvement in sub-tomogram averaging by ICON indicates its great potential in the future application of high resolution structural determination of macromolecules in situ. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
关键词	Compressed sensing Electron tomography Missing wedge NUFFT Sub-tomogram averaging
DOI	10.1016/j.jsb.2016.04.004
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of Chinese Academy of Sciences[XDB08030202] ; National Basic Research Program (973 Program) of Ministry of Science and Technology of China[2014CB910700] ; National Natural Science Foundation of China[61232001] ; National Natural Science Foundation of China[61502455] ; National Natural Science Foundation of China[61472397] ; National Natural Science Foundation of China[31470037] ; National Natural Science Foundation of China[31100617]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号	WOS:000377735300011
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	被引频次：59[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/8361
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhang, Fa; Sun, Fei
作者单位	1.Chinese Acad Sci, Inst Biophys, Natl Key Lab Biomacromol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Ctr Biol Imaging, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Deng, Yuchen,Chen, Yu,Zhang, Yan,et al. ICON: 3D reconstruction with 'missing-information' restoration in biological electron tomography[J]. JOURNAL OF STRUCTURAL BIOLOGY,2016,195(1):100-112.
APA	Deng, Yuchen,Chen, Yu,Zhang, Yan,Wang, Shengliu,Zhang, Fa,&Sun, Fei.(2016).ICON: 3D reconstruction with 'missing-information' restoration in biological electron tomography.JOURNAL OF STRUCTURAL BIOLOGY,195(1),100-112.
MLA	Deng, Yuchen,et al."ICON: 3D reconstruction with 'missing-information' restoration in biological electron tomography".JOURNAL OF STRUCTURAL BIOLOGY 195.1(2016):100-112.