Opposing roles and potential antagonistic mechanism between TGF-beta and BMP pathways: Implications for cancer progression

doi:10.1016/j.ebiom.2019.02.033

	Opposing roles and potential antagonistic mechanism between TGF-beta and BMP pathways: Implications for cancer progression
	Ning, Junya 1,2; Zhao, Yi 3; Ye, Yingnan 1; Yu, Jinpu 1,2
	2019-03-01
发表期刊	EBIOMEDICINE
ISSN	2352-3964
卷号	41 页码:702-710
摘要	The transforming growth factor beta (TGF-beta) superfamily participates in tumour proliferation, apoptosis, differentiation, migration, invasion, immune evasion and extracellular matrix remodelling. Genetic deficiency in distinct components of TGF-beta and BMP-induced signalling pathways or their excessive activation has been reported to regulate the development and progression of some cancers. As more in-depth studies about this superfamily have been conducted, more evidence suggests that the TGF-beta and BMP pathways play an opposing role. The cross-talk of these 2 pathways has been widely studied in kidney disease and bone formation, and the opposing effects have also been observed in some cancers. However, the antagonistic mechanisms are still insufficiently investigated in cancer. In this review, we aim to display more evidences and possible mechanisms accounting for the antagonism between these 2 pathways, which might provide some clues for further study in cancer. (c) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://reativecommons.org/licenses/by-nc-nd/4.0/).
关键词	TGF-beta BMP cancer antagonistic potential mechanism
DOI	10.1016/j.ebiom.2019.02.033
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81872143,81472473] ; National Natural Science Foundation of China[81702280] ; National Natural Science Foundation of China[81272360] ; Key Project of Tianjin Health and Family Planning Commission[16KG126]
WOS研究方向	General & Internal Medicine ; Research & Experimental Medicine
WOS类目	Medicine, General & Internal ; Medicine, Research & Experimental
WOS记录号	WOS:000464321900080
出版者	ELSEVIER SCIENCE BV
引用统计	被引频次：56[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/4266
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Yu, Jinpu
作者单位	1.Tianjin Med Univ Canc Inst & Hosp, Canc Mol Diagnost Core, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy,Tianjins Clin Res, Tianjin, Peoples R China 2.Tianjin Med Univ Canc Inst & Hosp, Dept Immunol, Natl Clin Res Ctr Canc, Key Lab Canc Immunol & Biotherapy,Tianjins Clin R, Tianjin, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, State Key Lab Comp Architecture, Key Lab Intelligent Informat Proc,Adv Comp Res Ct, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Ning, Junya,Zhao, Yi,Ye, Yingnan,et al. Opposing roles and potential antagonistic mechanism between TGF-beta and BMP pathways: Implications for cancer progression[J]. EBIOMEDICINE,2019,41:702-710.
APA	Ning, Junya,Zhao, Yi,Ye, Yingnan,&Yu, Jinpu.(2019).Opposing roles and potential antagonistic mechanism between TGF-beta and BMP pathways: Implications for cancer progression.EBIOMEDICINE,41,702-710.
MLA	Ning, Junya,et al."Opposing roles and potential antagonistic mechanism between TGF-beta and BMP pathways: Implications for cancer progression".EBIOMEDICINE 41(2019):702-710.