A highly accurate Augmented Matched Interface and Boundary method for heat dissipation in tumor anatomies

doi:10.1016/j.jtherbio.2025.104299

	A highly accurate Augmented Matched Interface and Boundary method for heat dissipation in tumor anatomies
	Xu, Jiatian 1; Guan, Zhen 2; Li, Chuan 1
	2025-10-01
发表期刊	JOURNAL OF THERMAL BIOLOGY
ISSN	0306-4565
卷号	133 页码:13
摘要	Hyperthermia therapy stands out as a promising complementary cancer treatment because it targets tumor cells by their thermal sensitivity. Accurate simulation of heat distribution in complex tumor geometries is critical for treatment planning and delivery. Pennes' bioheat equation provides a widely-used framework to describe thermal transport in perfused biological tissues, but applying it to complex tumor geometries remains computationally challenging. We developed an advanced computational framework by combining Pennes' bioheat model and a new adaptive Augmented Matched Interface and Boundary (AMIB) method to accurately simulate heat dissipation in realistic tumor anatomies. CT scans are processed through edge-detection algorithms to identify the tumor boundary. A pair of coupled parametric cubic splines is created from a set of selected boundary points to reconstruct the tumor outline. Numerical schemes for boundary calculations are designed to support the AMIB method in solving Pennes' bioheat equation within the tumor. The AMIB method functions on Cartesian grids, achieving a second-order convergence in time and fourth-order convergence in space without requiring complex mesh generation. Numerical experiments demonstrate unconditional stability, high-order convergence rates, and high efficiency of the AMIB method in simulating hyperthermia treatments. The proposed computational pipeline offers a generalizable approach for image-guided thermal therapy simulations involving irregular tissue geometries. This study helps progress towards thermal modeling platforms that support hyperthermia cancer therapy through image-guided clinical applications.
关键词	Hyperthermia therapy (HT) Pennes' bioheat equation Augmented Matched Interface and Boundary (AMIB) method Cancer treatments
DOI	10.1016/j.jtherbio.2025.104299
收录类别	SCI
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Zoology
WOS类目	Biology ; Zoology
WOS记录号	WOS:001608345600001
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/41603
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Li, Chuan
作者单位	1.West Chester Univ Penn West Chester, Dept Math, W Chester, PA 19383 USA 2.Chinese Acad Sci, Inst Comp Technol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jiatian,Guan, Zhen,Li, Chuan. A highly accurate Augmented Matched Interface and Boundary method for heat dissipation in tumor anatomies[J]. JOURNAL OF THERMAL BIOLOGY,2025,133:13.
APA	Xu, Jiatian,Guan, Zhen,&Li, Chuan.(2025).A highly accurate Augmented Matched Interface and Boundary method for heat dissipation in tumor anatomies.JOURNAL OF THERMAL BIOLOGY,133,13.
MLA	Xu, Jiatian,et al."A highly accurate Augmented Matched Interface and Boundary method for heat dissipation in tumor anatomies".JOURNAL OF THERMAL BIOLOGY 133(2025):13.