HERB 2.0: an updated database integrating clinical and experimental evidence for traditional Chinese medicine

doi:10.1093/nar/gkae1037

	HERB 2.0: an updated database integrating clinical and experimental evidence for traditional Chinese medicine
	Gao, Kai 1,2,3; Liu, Liu 1; Lei, Shuangshuang 1; Li, Zhinong 2; Huo, Peipei 2; Wang, Zhihao 2; Dong, Lei 1; Deng, Wenxin 1; Bu, Dechao 2; Zeng, Xiaoxi 4; Li, Chun 5; Zhao, Yi 1,2; Zhang, Wei 4; Wang, Wei 5; Wu, Yang 2
	2024-11-18
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
页码	11
摘要	Clinical trials and meta-analyses are considered high-level medical evidence with solid credibility . However , such clinical evidence for traditional Chinese medicine (TCM) is scattered, requiring a unified entrance to navigate all available evaluations on TCM therapies under modern standards. Besides, novel experimental evidence has continuously accumulated for TCM since the publication of HERB 1.0. Therefore, we updated the HERB database to integrate four types of evidence for TCM: (i) we curated 8558 clinical trials and 8032 meta-analyses information for TCM and extracted clear clinical conclusions for 1941 clinical trials and 593 meta-analyses with companion supporting papers. (ii) we updated experimental evidence for TCM, increased the number of high-throughput experiments to 2231, and curated references to 6 644. We newly added high-throughput experiments for 376 diseases and evaluated all pairwise similarities among TCM herbs / ingredients /formulae, modern drugs and diseases. (iii) we provide an automatic analyzing interface for users to upload their gene expression profiles and map them to our curated datasets. (iv) we built knowledge graph representations of HERB entities and relationships to retrieve TCM knowledge better . In summary , HERB 2.0 represents rich data type, content, utilization, and visualization improvements to support TCM research and guide modern drug discovery. [GRAPHICS]
DOI	10.1093/nar/gkae1037
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2021YFC2500203] ; National Natural Science Foundation of China[32070670] ; National Natural Science Foundation of China[92474204] ; National Natural Science Foundation of China[32341019] ; Beijing Natural Science Foundation[L222007] ; Ningbo major project for high-level medical and healthcare teams[2023030615] ; Ningbo major project for high-level medical and healthcare teams[2024020919] ; Ningbo Science and Technology Innovation Yongjiang 2035 Project[2024Z229] ; Major Project of Guangzhou National Laboratory[GZNL2023A03001] ; National Key R&D Program of China
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:001358732900001
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/41181
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhao, Yi; Zhang, Wei; Wang, Wei; Wu, Yang
作者单位	1.Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Comp Technol, Res Ctr Ubiquitous Comp Syst, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China 3.Ningbo 2 Hosp, Dept Resp & Crit Care Med, Ningbo 315010, Peoples R China 4.Sichuan Univ, West China Hosp, West China Biomed Big Data Ctr, Chengdu 610041, Peoples R China 5.Guangzhou Univ Chinese Med, State Key Lab Tradit Chinese Med Syndrome, Guangzhou 510006, Peoples R China
推荐引用方式 GB/T 7714	Gao, Kai,Liu, Liu,Lei, Shuangshuang,et al. HERB 2.0: an updated database integrating clinical and experimental evidence for traditional Chinese medicine[J]. NUCLEIC ACIDS RESEARCH,2024:11.
APA	Gao, Kai.,Liu, Liu.,Lei, Shuangshuang.,Li, Zhinong.,Huo, Peipei.,...&Wu, Yang.(2024).HERB 2.0: an updated database integrating clinical and experimental evidence for traditional Chinese medicine.NUCLEIC ACIDS RESEARCH,11.
MLA	Gao, Kai,et al."HERB 2.0: an updated database integrating clinical and experimental evidence for traditional Chinese medicine".NUCLEIC ACIDS RESEARCH (2024):11.