Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration

doi:10.1016/j.isci.2024.109407

	Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration
	Li, Hongyi 1,2; Li, Bei 1; Luo, Wenqi 3; Qi, Xi 4; Hao, You 5; Yang, Chaozhi 6; Li, Wenqing 1,7; Li, Jiazheng 7; Hua, Zhen 7; Guo, Tan 8; Zheng, Zhijian 9; Yu, Xue 10; Liu, Lei 11; Zhao, Jianping 10; Li, Tiantian 10; Huang, Dahai 2; Hu, Jun 12,13; Li, Zongmin 6; Wang, Fang 10; Li, Hua 5; Ma, Chao 14,15; Ji, Fusui 10
	2024-04-19
发表期刊	ISCIENCE
卷号	27 期号:4 页码:22
摘要	Converging studies showed interstitial fluid (ISF) adjacent to blood vessels flows in adventitia along vasculature into heart and lungs. We aim to reveal circulatory pathways and regulatory mechanism of such adventitial ISF flow in rat model. By MRI, real-time fluorescent imaging, micro -CT, and histological analysis, ISF was found to flow in adventitial matrix surrounded by fascia and along systemic vessels into heart, then flow into lungs via pulmonary arteries and back to heart via pulmonary veins, which was neither perivascular tissues nor blood or lymphatic vessels. Under physiological conditions, speckle -like adventitial ISF flow rate was positively correlated with heart rate, increased when holding breath, became pulsative during heavy breathing. During cardiac or respiratory cycle, each dilation or contraction of heart or lungs can generate to-and-fro adventitial ISF flow along femoral veins. Discovered regulatory mechanisms of adventitial ISF flow along vasculature by heart and lungs will revolutionize understanding of cardiovascular system.
DOI	10.1016/j.isci.2024.109407
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82050004] ; Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine[ZYYCXTD-D-202202] ; Beijing Hospital Clinical Research 121 Project[121 -2016002]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001228026300001
出版者	CELL PRESS
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/40073
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Li, Hongyi; Li, Hua; Ma, Chao; Ji, Fusui
作者单位	1.Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Res Ctr Interstitial Fluid Circulat, Beijing 100730, Peoples R China 2.Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Geriatr, Beijing 100730, Peoples R China 3.Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Cardiac Surg, Beijing 100730, Peoples R China 4.Peking Univ, Beijing Hosp, Inst Geriatr Med, Chinese Acad Med Sci,Sch Clin Med 5, Beijing 100730, Peoples R China 5.Chinese Acad Sci, Inst Comp Technol, Beijing 100190, Peoples R China 6.China Univ Petr East China, Sch Comp Sci & Technol, Qingdao 266580, Peoples R China 7.Beijing Hosp, Inst Geriatr Med, Chinese Acad Med Sci, Natl Ctr Gerontol, Beijing 100730, Peoples R China 8.Beijing Hosp, Inst Geriatr Med, Chinese Acad Med Sci, Natl Ctr Gerontol,Dept Radiol, Beijing 100730, Peoples R China 9.Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Acupuncture, Beijing 100730, Peoples R China 10.Chinese Acad Med Sci, Beijing Hosp, Natl Ctr Gerontol Inst Geriatr Med, Dept Cardiol, Beijing 100730, Peoples R China 11.Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Pharm, Beijing 100730, Peoples R China 12.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 13.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Shanghai 201210, Peoples R China 14.Chinese Acad Med Sci, Inst Basic Med Sci, Peking Union Med Coll, Sch Basic Med,Dept Human Anat Histol & Embryol, Beijing 100005, Peoples R China 15.Chinese Inst Brain Res, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Hongyi,Li, Bei,Luo, Wenqi,et al. Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration[J]. ISCIENCE,2024,27(4):22.
APA	Li, Hongyi.,Li, Bei.,Luo, Wenqi.,Qi, Xi.,Hao, You.,...&Ji, Fusui.(2024).Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration.ISCIENCE,27(4),22.
MLA	Li, Hongyi,et al."Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration".ISCIENCE 27.4(2024):22.