Association of miR-155 and MIR155HG polymorphisms with cancer risk: A meta-analysis

doi:10.4103/jcrt.jcrt_913_21

	Association of miR-155 and MIR155HG polymorphisms with cancer risk: A meta-analysis
	Zou, Zhishan 1; Lu, Hui 1; Zhang, Wenliang 2,3; Li, Yiming 1; He, Yi 1; Lin, Huancai 1; Zhao, Wei 1; Yu, Dongsheng 1; Zeng, Binghui 1
	2021-11-01
发表期刊	JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
ISSN	0973-1482
卷号	17 期号:5 页码:1209-+
摘要	Background: Analysis of emerging data shows that miRNAs, including miR-155, play important roles in tumorigenesis. Several studies have indicated that miR-155 and MIR155HG polymorphisms may be related to cancer risk, but the association was controversial. Therefore, we conducted this first-reported comprehensive meta-analysis of the association of miR-155 and MIR155HG polymorphisms with cancer risk. Materials and Methods: We searched several databases, including PubMed, Embase, and Web of Science, to identify the eligible studies reporting the association of miR-155 and MIR155HG polymorphisms with cancer risk. We calculated the pooled odds ratios (ORs) and 95% confidence intervals (CIs) to analyze the association. Stata software (version 16.0) was used to analyze the data we collected. Results: After being carefully and strictly screened, eight articles reporting on six common single-nucleotide polymorphisms consisting of 6184 cases and 6896 controls were included in this meta-analysis. The six polymorphisms included were rs767649 (T>A), rs928883 (A>G), rs2829803 (G>A), rs1893650 (T>C), rs4143370 (G>C), and rs12482371 (T>C). Our results showed that, in the overall analysis, heterozygotes increased cancer risk, with a marginal P value, compared with wild-type (OR = 1.06, 95% CI = 1.00-1.12, P = 0.062). Subsequent analyses showed that only rs767649 was associated with an increased risk of non-small-cell lung cancer (NSCLC) in an allele model (T vs. A: OR = 1.15, 95% CI = 1.04-1.26, P = 0.007), a homozygote model (TT vs. AA: OR = 1.31, 95% CI = 1.06-1.60, P = 0.011), and a recessive model (TT vs. AT + AA: OR = 1.30, 95% CI = 1.08-1.55, P = 0.005). Conclusion: The present meta-analysis indicates that the rs767649 polymorphism might be a potential factor for NSCLC risk; however, more studies should be conducted to confirm these findings.
关键词	Cancer meta-analysis miR-155 non-small-cell lung cancer polymorphism
DOI	10.4103/jcrt.jcrt_913_21
收录类别	SCI
语种	英语
资助项目	Fundamental Research Funds of the Central Universities, Sun Yat-Sen University[19ykpy86] ; China Postdoctoral Science Foundation[2020M673023] ; National Natural Science Foundation of China[81873711] ; National Natural Science Foundation of China[82073378]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000754557100009
出版者	WOLTERS KLUWER MEDKNOW PUBLICATIONS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/18989
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Yu, Dongsheng; Zeng, Binghui
作者单位	1.Sun Yat Sen Univ, Guanghua Sch Stomatol, Hosp Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R China 2.Univ Hong Kong Shenzhen Hosp, Dept Pediat, Shenzhen, Peoples R China 3.Chinese Acad Sci, Ctr High Performance Comp, Joint Engn Res Ctr Hlth Big Data Intelligent Anal, Shenzhen Inst Adv Technol, Shenzhen, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zou, Zhishan,Lu, Hui,Zhang, Wenliang,et al. Association of miR-155 and MIR155HG polymorphisms with cancer risk: A meta-analysis[J]. JOURNAL OF CANCER RESEARCH AND THERAPEUTICS,2021,17(5):1209-+.
APA	Zou, Zhishan.,Lu, Hui.,Zhang, Wenliang.,Li, Yiming.,He, Yi.,...&Zeng, Binghui.(2021).Association of miR-155 and MIR155HG polymorphisms with cancer risk: A meta-analysis.JOURNAL OF CANCER RESEARCH AND THERAPEUTICS,17(5),1209-+.
MLA	Zou, Zhishan,et al."Association of miR-155 and MIR155HG polymorphisms with cancer risk: A meta-analysis".JOURNAL OF CANCER RESEARCH AND THERAPEUTICS 17.5(2021):1209-+.