Institute of Computing Technology, Chinese Academy IR
| Microbiome Resilience and Health Implications for People in Half-Year Travel | |
| Cheng, Mingyue1; Liu, Hong1,2; Han, Maozhen1; Li, Shuai Cheng3; Bu, Dongbo4,5; Sun, Shiwei4,5; Hu, Zhiqiang2; Yang, Pengshuo1; Wang, Rui2; Liu, Yawen2; Chen, Feng2; Peng, Jianjun2; Peng, Hong2; Song, Hongxing2; Xia, Yang2; Chu, Liqun2; Zhou, Quan2; Guan, Feng2; Wu, Jing2; Tan, Guangming4,5; Ning, Kang1 | |
| 2022-02-24 | |
| 发表期刊 | FRONTIERS IN IMMUNOLOGY
 |
| ISSN | 1664-3224 |
| 卷号 | 13页码:15 |
| 摘要 | Travel entail change in geography and diet, both of which are known as determinant factors in shaping the human gut microbiome. Additionally, altered gut microbiome modulates immunity, bringing about health implications in humans. To explore the effects of the mid-term travel on the gut microbiome, we generated 16S rRNA gene and metagenomic sequencing data from longitudinal samples collected over six months. We monitored dynamic trajectories of the gut microbiome variation of a Chinese volunteer team (VT) in their whole journey to Trinidad and Tobago (TAT). We found gut microbiome resilience that VT's gut microbial compositions gradually transformed to the local TAT's enterotypes during their six-month stay in TAT, and then reverted to their original enterotypes after VT's return to Beijing in one month. Moreover, we identified driven species in this bi-directional plasticity that could play a role in immunity modulation, as exemplified by Bacteroides dorei that attenuated atherosclerotic lesion formation and effectively suppressed proinflammatory immune response. Another driven species P. copri could play a crucial role in rheumatoid arthritis pathogenesis, a chronic autoimmune disease. Carbohydrate-active enzymes are often implicated in immune and host-pathogen interactions, of which glycoside hydrolases were found decreased but glycosyltransferases and carbohydrate esterases increased during the travel; these functions were then restored after VT' returning to Beijing. Furthermore, we discovered these microbial changes and restoration were mediated by VT people's dietary changes. These findings indicate that half-year travel leads to change in enterotype and functional patterns, exerting effects on human health. Microbial intervention by dietary guidance in half-year travel would be conducive to immunity modulation for maintaining health. |
| 关键词 | travel enterotype microbiome bi-directional plasticity resilience dietary shift immunity health |
| DOI | 10.3389/fimmu.2022.848994 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[31871334] ; National Natural Science Foundation of China[32071465] ; National Natural Science Foundation of China[31671374] ; National Natural Science Foundation of China[31327901] ; National Natural Science Foundation of China[31671369] ; National Natural Science Foundation of China[31770775] ; National Natural Science Foundation of China[61521092] ; National Natural Science Foundation of China[91430218] ; National Natural Science Foundation of China[61472395] ; National Natural Science Foundation of China[61432018] ; National Key Research and Development Program of China[2018YFC0910502] ; National Key Research and Development Program of China[2018YFC0910405] ; GRF Research Project[9042348] ; GRF Research Project[CityU11257316] |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| WOS记录号 | WOS:000768026900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.204/handle/2XEOYT63/18949 |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Wu, Jing; Tan, Guangming; Ning, Kang |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Key Lab Mol Biophys, Minist Educ,Dept Bioinformat & Syst Biol,Coll Lif, Hubei Key Lab Bioinformat & Mol Imaging,Ctr AI Bi, Wuhan, Peoples R China 2.Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China 3.City Univ Hong Kong, Dept Comp Sci, Hong Kong, Peoples R China 4.Chinese Acad Sci, Key Lab Intelligent Informat Proc, State Lab Comp Architecture, Inst Comp Technol, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Sch Comp & Control, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Mingyue,Liu, Hong,Han, Maozhen,et al. Microbiome Resilience and Health Implications for People in Half-Year Travel[J]. FRONTIERS IN IMMUNOLOGY,2022,13:15. |
| APA | Cheng, Mingyue.,Liu, Hong.,Han, Maozhen.,Li, Shuai Cheng.,Bu, Dongbo.,...&Ning, Kang.(2022).Microbiome Resilience and Health Implications for People in Half-Year Travel.FRONTIERS IN IMMUNOLOGY,13,15. |
| MLA | Cheng, Mingyue,et al."Microbiome Resilience and Health Implications for People in Half-Year Travel".FRONTIERS IN IMMUNOLOGY 13(2022):15. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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