Fragment-HMM: A new approach to protein structure prediction

doi:10.1110/ps.036442.108

	Fragment-HMM: A new approach to protein structure prediction
	Li, Shuai Cheng 2; Bu, Dongbo 2,3; Xu, Jinbo 1; Li, Ming 2
	2008-11-01
发表期刊	PROTEIN SCIENCE
ISSN	0961-8368
卷号	17 期号:11 页码:1925-1934
摘要	We designed a simple position-specific hidden Markov model to predict protein structure. Our new framework naturally repeats itself to converge to a final target, conglomerating fragment assembly, clustering, target selection, refinement, and consensus, all in one process. Our initial implementation of this theory converges to within 6 angstrom of the native structures for 100% of decoys on all six standard benchmark proteins used in ROSETTA (discussed by Simons and colleagues in a recent paper), which achieved only 14%-94% for the same data. The qualities of the best decoys and the final decoys our theory converges to are also notably better.
关键词	protein structure prediction hidden Markov model fragment assembly
DOI	10.1110/ps.036442.108
收录类别	SCI
语种	英语
资助项目	NSERC[OGP0046506] ; Canada Research Chair program ; MITACS ; NSF of China[60496324] ; Chinese Government Scholarship
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000260423400006
出版者	WILEY-BLACKWELL
引用统计	被引频次：43[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/11070
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Xu, Jinbo
作者单位	1.Toyota Technol Inst, Chicago, IL 60637 USA 2.Univ Waterloo, David R Cheriton Sch Comp Sci, Waterloo, ON N2L 3G1, Canada 3.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Li, Shuai Cheng,Bu, Dongbo,Xu, Jinbo,et al. Fragment-HMM: A new approach to protein structure prediction[J]. PROTEIN SCIENCE,2008,17(11):1925-1934.
APA	Li, Shuai Cheng,Bu, Dongbo,Xu, Jinbo,&Li, Ming.(2008).Fragment-HMM: A new approach to protein structure prediction.PROTEIN SCIENCE,17(11),1925-1934.
MLA	Li, Shuai Cheng,et al."Fragment-HMM: A new approach to protein structure prediction".PROTEIN SCIENCE 17.11(2008):1925-1934.