Detecting chimeric 5 '/3 ' UTRs with cross-chromosomal splicing by bioinformatics

doi:10.1360/03wc0611

	Detecting chimeric 5 '/3 ' UTRs with cross-chromosomal splicing by bioinformatics
	Zhang, ZH ; Zhang, Y ; Shi, BC ; Deng, W ; Zhao, Y ; Chen, RS
	2004-05-01
发表期刊	CHINESE SCIENCE BULLETIN
ISSN	1001-6538
卷号	49 期号:10 页码:1051-1054
摘要	The 5'/3'UTRs of mRNA are crucial in translational regulation, and several serious diseases are believed to be associated with abnormal splicing of these parts of the mRNA sequence. In this work a novel method which uses sequence alignment database searching for detecting chimeric 5'3' UTRs with cross-chromosomal splicing is reported. Eight highly credible instances of cross-chromosomal splicing have been found using this method, representing additional confirmation of the existence of cross-chromosomal splicing events provided by bioinformatics tools. Since no conserved motif has been found in any of the eight instances, and at the same time current prediction algorithms produce only trivial secondary structures at the "splicing sites", it is not possible to identify any specific signal leading to the splicing.
关键词	5 '/3 ' UTRs mRNA trans-splicing chromosomal translocations chimeric
DOI	10.1360/03wc0611
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000223146800013
出版者	SCIENCE CHINA PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/9805
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chen, RS
作者单位	1.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zhang, ZH,Zhang, Y,Shi, BC,et al. Detecting chimeric 5 '/3 ' UTRs with cross-chromosomal splicing by bioinformatics[J]. CHINESE SCIENCE BULLETIN,2004,49(10):1051-1054.
APA	Zhang, ZH,Zhang, Y,Shi, BC,Deng, W,Zhao, Y,&Chen, RS.(2004).Detecting chimeric 5 '/3 ' UTRs with cross-chromosomal splicing by bioinformatics.CHINESE SCIENCE BULLETIN,49(10),1051-1054.
MLA	Zhang, ZH,et al."Detecting chimeric 5 '/3 ' UTRs with cross-chromosomal splicing by bioinformatics".CHINESE SCIENCE BULLETIN 49.10(2004):1051-1054.