Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity

doi:10.1038/srep11338

	Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity
	Chen, Xing 1,2; Yan, Chenggang Clarence 3; Luo, Cai 3; Ji, Wen 4; Zhang, Yongdong 5; Dai, Qionghai 3
	2015-06-10
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	5 页码:12
摘要	Increasing evidence has indicated that plenty of lncRNAs play important roles in many critical biological processes. Developing powerful computational models to construct lncRNA functional similarity network based on heterogeneous biological datasets is one of the most important and popular topics in the fields of both lncRNAs and complex diseases. Functional similarity network consturction could benefit the model development for both lncRNA function inference and lncRNA-disease association identification. However, little effort has been attempted to analysis and calculate lncRNA functional similarity on a large scale. In this study, based on the assumption that functionally similar lncRNAs tend to be associated with similar diseases, we developed two novel lncRNA functional similarity calculation models (LNCSIM). LNCSIM was evaluated by introducing similarity scores into the model of Laplacian Regularized Least Squares for LncRNA-Disease Association (LRLSLDA) for lncRNA-disease association prediction. As a result, new predictive models improved the performance of LRLSLDA in the leave-one-out cross validation of various known lncRNA-disease associations datasets. Furthermore, some of the predictive results for colorectal cancer and lung cancer were verified by independent biological experimental studies. It is anticipated that LNCSIM could be a useful and important biological tool for human disease diagnosis, treatment, and prevention.
DOI	10.1038/srep11338
收录类别	SCI
语种	英语
资助项目	National Natural Science of Foundation of China[11301517] ; National Natural Science of Foundation of China[61472203] ; National Natural Science of Foundation of China[61327902] ; National Center for Mathematics and Interdisciplinary Sciences, CAS
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000356093500001
出版者	NATURE PUBLISHING GROUP
引用统计	被引频次：189[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/9737
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chen, Xing
作者单位	1.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 3.Tsinghua Univ, Dept Automat, Beijing 100084, Peoples R China 4.Chinese Acad Sci, Inst Comp Technol, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xing,Yan, Chenggang Clarence,Luo, Cai,et al. Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity[J]. SCIENTIFIC REPORTS,2015,5:12.
APA	Chen, Xing,Yan, Chenggang Clarence,Luo, Cai,Ji, Wen,Zhang, Yongdong,&Dai, Qionghai.(2015).Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity.SCIENTIFIC REPORTS,5,12.
MLA	Chen, Xing,et al."Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity".SCIENTIFIC REPORTS 5(2015):12.