Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy

doi:10.1038/srep23393

	Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy
	Luo, Zhenyu 1,4; Zheng, Mingbin 1,2; Zhao, Pengfei 1,4; Chen, Ze 1; Siu, Fungming 3; Gong, Ping 1; Gao, Guanhui 1; Sheng, Zonghai 1; Zheng, Cuifang 1; Ma, Yifan 1; Cai, Lintao 1
	2016-03-18
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	6 页码:11
摘要	Photodynamic therapy has been increasingly applied in clinical cancer treatments. However, native hypoxic tumoural microenvironment and lacking oxygen supply are the major barriers hindering photodynamic reactions. To solve this problem, we have developed biomimetic artificial red cells by loading complexes of oxygen-carrier (hemoglobin) and photosensitizer (indocyanine green) for boosted photodynamic strategy. Such nanosystem provides a coupling structure with stable self-oxygen supply and acting as an ideal fluorescent/photoacoustic imaging probe, dynamically monitoring the nanoparticle biodistribution and the treatment of PDT. Upon exposure to near-infrared laser, the remote-triggered photosensitizer generates massive cytotoxic reactive oxygen species (ROS) with sufficient oxygen supply. Importantly, hemoglobin is simultaneously oxidized into the more active and resident ferryl-hemoglobin leading to persistent cytotoxicity. ROS and ferryl-hemoglobin synergistically trigger the oxidative damage of xenograft tumour resulting in complete suppression. The artificial red cells with self-monitoring and boosted photodynamic efficacy could serve as a versatile theranostic platform.
DOI	10.1038/srep23393
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31571013] ; National Natural Science Foundation of China[21203237] ; National Natural Science Foundation of China[81401520] ; National Natural Science Foundation of China[81171446] ; Instrument Developing Project of the CAS[YZ201439] ; Key International S&T Cooperation Project[2015DFH50230] ; Guangdong Science and Technology Key Project[2012A061400013] ; Guangdong Science and Technology Key Project[2012B090400043] ; Shenzhen Science and Technology Program[KQCX20140521115045447] ; Shenzhen Science and Technology Program[GJHS20140610152828690] ; Shenzhen Bioactive Materials Engineering Lab for Medicine[[2013]154] ; China Postdoctoral Science Foundation Funded Project[2015M572387] ; Dongguan project on Social science and Technology Development[2015108101019] ; Guangdong medical university fund[2XB14015]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000372482900001
出版者	NATURE PUBLISHING GROUP
引用统计	被引频次：127[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/8708
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zheng, Mingbin; Ma, Yifan; Cai, Lintao
作者单位	1.Chinese Acad Sci, SIAT, Guangdong Key Lab Nanomed, CAS Key Lab Hlth Informat,Inst Biomed & Biotechno, Shenzhen 518055, Peoples R China 2.Guangdong Med Univ, Dept Chem, Dongguan 523808, Peoples R China 3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Adv Comp & Digital Engn, Ctr High Performance Comp, Shenzhen 518055, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Luo, Zhenyu,Zheng, Mingbin,Zhao, Pengfei,et al. Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy[J]. SCIENTIFIC REPORTS,2016,6:11.
APA	Luo, Zhenyu.,Zheng, Mingbin.,Zhao, Pengfei.,Chen, Ze.,Siu, Fungming.,...&Cai, Lintao.(2016).Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy.SCIENTIFIC REPORTS,6,11.
MLA	Luo, Zhenyu,et al."Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy".SCIENTIFIC REPORTS 6(2016):11.