Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer

doi:10.1016/j.biomaterials.2016.03.037

	Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer
	Hu, Dehong 1,2; Sheng, Zonghai 1,2; Gao, Guanhui 4; Siu, Fungming 3; Liu, Chengbo 2; Wan, Qian 2; Gong, Ping 1; Zheng, Hairong 2; Ma, Yifan 1; Cai, Lintao 1
	2016-07-01
发表期刊	BIOMATERIALS
ISSN	0142-9612
卷号	93 页码:10-19
摘要	Photodynamic therapy (PDT) is a noninvasive and effective approach for cancer treatment. The main bottlenecks of clinical PDT are poor selectivity of photosensitizer and inadequate oxygen supply resulting in serious side effects and low therapeutic efficiency. Herein, a thermal-modulated reactive oxygen species (ROS) strategy using activatable human serum albumin-chlorin e6 nanoassemblies (HSA-Ce6 NAs) for promoting PDT against cancer is developed. Through intermolecular disulfide bond crosslinking and hydrophobic interaction, Ce6 photosensitizer is effectively loaded into the HSA NAs, and the obtained HSA-Ce6 NAs exhibit excellent reduction response, as well as enhanced tumor accumulation and retention. By the precision control of the overall body temperature instead of local tumor temperature increasing from 37 degrees C to 43 degrees C, the photosensitization reaction rate of HSA-Ce6 NAs increases 20%, and the oxygen saturation of tumor tissue raise 52%, significantly enhancing the generation of ROS for promoting PDT. Meanwhile, the intrinsic fluorescence and photoacoustic properties, and the chelating characteristic of porphyrin ring can endow the HSA-Ce6 NAs with fluorescence, photoacoustic and magnetic resonance triple-modal imaging functions. Upon irradiation of low-energy near-infrared laser, the tumors are completely suppressed without tumor recurrence and therapy-induced side effects. The robust thermal-modulated ROS strategy combined with albumin-based activatable nanophotosensitizer is highly potential for multi-modal imaging-guided PDT and clinical translation. (C) 2016 Elsevier Ltd. All rights reserved.
关键词	Photodynamic therapy Thermal modulation Theranostics Multi-modal imaging Activatable nanophotosensitizer
DOI	10.1016/j.biomaterials.2016.03.037
收录类别	SCI
语种	英语
资助项目	Major State Basic Research Development Program of China (973 Program)[2015CB755500] ; Natural Science Foundation of China[31571013] ; Natural Science Foundation of China[81301272] ; Natural Science Foundation of China[81571745] ; Natural Science Foundation of China[81401521] ; Natural Science Foundation of China[21203237] ; Key International S&T Cooperation Project[2015DFH50230] ; Instrument Developing Project of the CAS[YZ201439] ; Science and Technology Innovation Fund of Shenzhen[JCYJ20150401145529015] ; Science and Technology Innovation Fund of Shenzhen[KQCX20140521115045447] ; Shenzhen Bioactive Materials Engineering Lab for Medicine[[2013]154] ; SIAT Innovation Program for Excellent Young Researchers[201301]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000375825500002
出版者	ELSEVIER SCI LTD
引用统计	被引频次：135[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/8582
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Sheng, Zonghai; Cai, Lintao
作者单位	1.Chinese Acad Sci, Guangdong Key Lab Nanomed, CAS Key Lab Hlth Informat, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Shenzhen 518055, Peoples R China 3.Chinese Acad Sci, Ctr High Performance Comp, Inst Adv Comp & Digital Engn, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 4.Leibniz Inst Forsch Verbund, Paul Drude Inst, Hausvogteipl 5-7, D-10117 Berlin, Germany
推荐引用方式 GB/T 7714	Hu, Dehong,Sheng, Zonghai,Gao, Guanhui,et al. Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer[J]. BIOMATERIALS,2016,93:10-19.
APA	Hu, Dehong.,Sheng, Zonghai.,Gao, Guanhui.,Siu, Fungming.,Liu, Chengbo.,...&Cai, Lintao.(2016).Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer.BIOMATERIALS,93,10-19.
MLA	Hu, Dehong,et al."Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer".BIOMATERIALS 93(2016):10-19.