A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

doi:10.1038/srep31716

	A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling
	Wu, Liangcai 1,2,3; Xu, Qianqian 2,4; Zhang, Haohai 1,2; Li, Ming 3; Zhu, Chengpei 1,2; Jiang, Minjie 3; Sang, Xinting 1,2; Zhao, Yi 1,2,3; Sun, Qiang 2,4; Zhao, Haitao 1,2
	2016-08-19
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	6 页码:8
摘要	Estrogen receptor signalling plays important regulatory roles in multiple mammalian physiological processes. Dysregulation of estrogen receptor (ER) expression and/or its associated signalling pathway is strongly associated with the development, progression, transition, and endocrine-resistance of breast cancer. Non-coding transcripts are essential regulators of almost every level of gene regulation. However, few long non-coding transcripts (lncRNAs) associated with the estrogen receptor signalling pathway have been well-described. We used array-based methods to identify 33 estrogen receptor agitation-related (ERAR) lncRNAs. A coding-non-coding gene co-expression network analysis suggested that 15 ERAR lncRNAs were associated with mitosis, DNA damage, and DNA repair. Kaplan-Meier analysis indicated that five ERAR lncRNAs selected using the Random Forest-Recursive Feature Elimination algorithm were significantly correlated with endocrine resistance-free survival and distant metastasis-free survival as well as disease free survival. Our results suggest that ERAR lncRNAs may serve as novel biomarkers for guiding breast cancer treatment and prognosis. Furthermore, our findings reveal a new avenue by which estrogen receptor signalling can be further explored.
DOI	10.1038/srep31716
收录类别	SCI
语种	英语
资助项目	International Science and Technology Cooperation Projects[2015DFA30650] ; International Science and Technology Cooperation Projects[2010DFB33720] ; Capital Special Research Project for Health Development[2014-2-4012] ; Capital research project for the characteristics clinical application[Z151100004015170] ; Program for New Century Excellent Talents in University[NCET-11-0288]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000381614400001
出版者	NATURE PUBLISHING GROUP
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/8061
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhao, Yi; Sun, Qiang; Zhao, Haitao
作者单位	1.Chinese Acad Med Sci, Dept Liver Surg, Peking Union Med Coll Hosp, Beijing, Peoples R China 2.Peking Union Med Coll, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing, Peoples R China 4.Chinese Acad Med Sci, Dept Breast Surg, Peking Union Med Coll Hosp, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wu, Liangcai,Xu, Qianqian,Zhang, Haohai,et al. A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling[J]. SCIENTIFIC REPORTS,2016,6:8.
APA	Wu, Liangcai.,Xu, Qianqian.,Zhang, Haohai.,Li, Ming.,Zhu, Chengpei.,...&Zhao, Haitao.(2016).A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling.SCIENTIFIC REPORTS,6,8.
MLA	Wu, Liangcai,et al."A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling".SCIENTIFIC REPORTS 6(2016):8.