dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers

doi:10.1093/nar/gkw1079

	dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers
	Yang, Zhen 1; Wu, Liangcai 2; Wang, Anqiang 2; Tang, Wei 3; Zhao, Yi 4; Zhao, Haitao 2; Teschendorff, Andrew E.1,5
	2017-01-04
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	45 期号:D1 页码:D812-D818
摘要	MicroRNAs (miRNAs) are often deregulated in cancer and are thought to play an important role in cancer development. Large amount of differentially expressed miRNAs have been identified in various cancers by using high-throughput methods. It is therefore quite important to make a comprehensive collection of these miRNAs and to decipher their roles in oncogenesis and tumor progression. In 2010, we presented the first release of dbDEMC, representing a database for collection of differentially expressed miRNAs in human cancers obtained from microarray data. Here we describe an update of the database. dbDEMC 2.0 documents 209 expression profiling data sets across 36 cancer types and 73 subtypes, and a total of 2224 differentially expressed miRNAs were identified. An easy-to-use web interface was constructed that allows users to make a quick search of the differentially expressed miRNAs in certain cancer types. In addition, a new function of 'meta-profiling' was added to view differential expression events according to user-defined miRNAs and cancer types. We expect this database to continue to serve as a valuable source for cancer investigation and potential clinical application related to miRNAs.
DOI	10.1093/nar/gkw1079
收录类别	SCI
语种	英语
资助项目	National Science Foundation of China[31571359] ; National Science Foundation of China[31401120] ; Youth Innovation Promotion Association ; CAS ; International Science and Technology Cooperation Projects[2015DFA30650]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000396575500113
出版者	OXFORD UNIV PRESS
引用统计	被引频次：257[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/7462
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhao, Haitao; Teschendorff, Andrew E.
作者单位	1.CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 2.Chinese Acad Med Sci & Peking Union Med Coll CAMS, Peking Union Med Coll Hosp, Dept Liver Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China 3.Tianjin Univ, Sch Biotechnol Engn, 135 Yaguan Rd, Tianjin, Peoples R China 4.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China 5.UCL, UCL Canc Inst, Statist Canc Gen, Paul OGorman Bldg,72 Huntley St, London WC1E 6BT, England
推荐引用方式 GB/T 7714	Yang, Zhen,Wu, Liangcai,Wang, Anqiang,et al. dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers[J]. NUCLEIC ACIDS RESEARCH,2017,45(D1):D812-D818.
APA	Yang, Zhen.,Wu, Liangcai.,Wang, Anqiang.,Tang, Wei.,Zhao, Yi.,...&Teschendorff, Andrew E..(2017).dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers.NUCLEIC ACIDS RESEARCH,45(D1),D812-D818.
MLA	Yang, Zhen,et al."dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers".NUCLEIC ACIDS RESEARCH 45.D1(2017):D812-D818.