Several microRNAs could predict survival in patients with hepatitis B-related liver cancer

doi:10.1038/srep45195

	Several microRNAs could predict survival in patients with hepatitis B-related liver cancer
	Ye Zhen 1,2,3; Zhao Xinghui 4; Wu Chao 1; Zhao Yi 5; Chen Jinwen 5; Gao Ruifang 1; Zhang Chao 6; Zhao Min 3; Guo Chunlei 1; Fang Yan 1; Du Lingfang 1; Shen Long 1; Shen Wenzhi 1; Luo Xiaohe 1; Xiang Rong 1,7,8
	2017-03-21
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7 页码:8
摘要	MicroRNAs as biomarkers play an important role in the tumorigenesis process, including hepatocellular carcinomas (HCCs). In this paper, we used The Cancer Genome Atlas (TCGA) database to mine hepatitis B-related liver cancer microRNAs that could predict survival in patients with hepatitis B-related liver cancer. There were 93 cases of HBV-HCC and 49 cases of adjacent normal controls included in the study. Kaplan-Meier survival analysis of a liver cancer group versus a normal control group of differentially expressed genes identified eight genes with statistical significance. Compared with the normal liver cell line, hepatocellular carcinoma cell lines had high expression of 8 microRNAs, albeit at different levels. A Cox proportional hazards regression model for multivariate analysis showed that four genes had a significant difference. We established classification models to distinguish short survival time and long survival time of liver cancers. Eight genes (mir9-3, mir10b, mir31, mir519c, mir522, mir3660, mir4784, and mir6883) were identified could predict survival in patients with HBV-HCC. There was a significant correlation between mir10b and mir31 and clinical stages (p < 0.05). A random forests model effectively estimated patient survival times.
DOI	10.1038/srep45195
收录类别	SCI
语种	英语
资助项目	National Basic Research Program of China 973 Program[2013CB967201]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000396852900001
出版者	NATURE PUBLISHING GROUP
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/7326
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Xiang Rong
作者单位	1.Nankai Univ, Sch Med, Dept Tumor Mol Biol, Tianjin 371000, Peoples R China 2.Taishan Med Univ, Sch Publ Hlth, Tai An 271016, Shandong, Peoples R China 3.Taian Cent Hosp, Dept Infect Dis, Tai An 271000, Shandong, Peoples R China 4.Beijing Inst Technol, Lab Vaccine & Antibody Engn, Beijing 100071, Peoples R China 5.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China 6.Shandong Agr Univ, Coll Informat Sci & Engn, Tai An 271000, Shandong, Peoples R China 7.Nankai Univ, Sch Med, 2011 Project Collaborat Innovat Ctr Biol Therapy, Tianjin 371000, Peoples R China 8.Nankai Univ, Sch Med, Minist Educ, Int Collaborat Lab Biol Med, Tianjin 371000, Peoples R China
推荐引用方式 GB/T 7714	Ye Zhen,Zhao Xinghui,Wu Chao,et al. Several microRNAs could predict survival in patients with hepatitis B-related liver cancer[J]. SCIENTIFIC REPORTS,2017,7:8.
APA	Ye Zhen.,Zhao Xinghui.,Wu Chao.,Zhao Yi.,Chen Jinwen.,...&Xiang Rong.(2017).Several microRNAs could predict survival in patients with hepatitis B-related liver cancer.SCIENTIFIC REPORTS,7,8.
MLA	Ye Zhen,et al."Several microRNAs could predict survival in patients with hepatitis B-related liver cancer".SCIENTIFIC REPORTS 7(2017):8.