The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma

doi:10.18632/oncotarget.16163

	The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma
	Zhao, Shuangtao 1,2; Fang, Shuangsang 3; Liu, Yanhua 4,5,6; Li, Xixi 4,7; Liao, Shengyou 3; Chen, Jinwen 3; Liu, Jingjia 3; Zhao, Lianhe 3; Li, Hui 3; Zhou, Wei 4,5,6; Shen, Wenzhi 4,5,6; Dong, Xiaoli 4,5,6; Xiang, Rong 4,5,6; Wang, Luhua 1,2; Zhao, Yi 3
	2017-05-23
发表期刊	ONCOTARGET
ISSN	1949-2553
卷号	8 期号:21 页码:34374-34386
摘要	Long non-coding RNAs are known to be involved in cancer progression, but their biological functions and prognostic values are still largely unexplored in diffuse large B-cell lymphoma. In this study, long non-coding RNAs expression was characterized in 1,403 samples including normal and diffuse large B-cell lymphoma by repurposing 7 microarray datasets. Compared with any stage of normal B cells, NONHSAG026900 expression was significantly decreased in tumor samples. And in germinal center B-cell subtype, the significantly higher expression of NONHSAG026900 indicated it was a favorable prognosis biomarker. Then the prognostic power of NONHSAG026900 was validated with another independent dataset and NONHSAG026900 improved the predictive power of International Prognostic Index as an independent factor. Moreover, functional prediction and validation demonstrated that NONHSAG026900 could inhibit cell cycle activity to restrain tumor proliferation. These findings identified NONHSAG026900 as a novel prognostic biomarker and offered a new therapeutic target for diffuse large B-cell lymphoma patients.
关键词	diffuse large B-cell lymphoma long non-coding RNA NONHSAG026900 prognosis biomarker
DOI	10.18632/oncotarget.16163
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31371320] ; National Natural Science Foundation of China[31401119] ; National Natural Science Foundation of China[61472397] ; National Natural Science Foundation of China[31501066]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000402051700035
出版者	IMPACT JOURNALS LLC
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/7242
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Xiang, Rong; Wang, Luhua; Zhao, Yi
作者单位	1.Peking Union Med Coll, Dept Radiat Oncol, Natl Canc Ctr, Canc Hosp, Beijing, Peoples R China 2.Chinese Acad Med Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing, Peoples R China 4.Nankai Univ, Sch Med, Tianjin, Peoples R China 5.Nankai Univ, Collaborat Innovat Ctr Biotherapy, Tianjin, Peoples R China 6.Tianjin Key Lab Tumor Microenvironm & Neurovasc R, Tianjin, Peoples R China 7.Nankai Univ, Dept Pathol, Tianjin, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Shuangtao,Fang, Shuangsang,Liu, Yanhua,et al. The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma[J]. ONCOTARGET,2017,8(21):34374-34386.
APA	Zhao, Shuangtao.,Fang, Shuangsang.,Liu, Yanhua.,Li, Xixi.,Liao, Shengyou.,...&Zhao, Yi.(2017).The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma.ONCOTARGET,8(21),34374-34386.
MLA	Zhao, Shuangtao,et al."The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma".ONCOTARGET 8.21(2017):34374-34386.