Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression

doi:10.3389/fgene.2017.00230

	Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression
	Luo, Haitao 1,2; Fang, Shuangsang 1,2; Sun, Liang 1; Liu, Zhiyong 3; Zhao, Yi 1
	2018-01-17
发表期刊	FRONTIERS IN GENETICS
ISSN	1664-8021
卷号	8 页码:8
摘要	RNA editing is a post-transcriptional event that leads to transcriptome diversity and has been shown to play important roles in tumorigenesis. However, dynamical changes and the functional significance of editing events during different cancer stages have not yet been characterized systematically. In this paper, we describe a comprehensive study of the RNA editome of four samples from different cancer stages for the same patient based on analysis of both whole-genome and transcriptome sequencing data. We identified 35,225 and 33,784 RNA editing events for poly(A)(+) and poly(A)(-) RNA sequencing data respectively in all four samples and show that 93 and 90% correspond to cancer stage-specific editing events. We also found that half of editing sites in 3' UTR of coding genes were microRNA targets and most of the sites in the coding regions could lead to non-synonymous amino acid changes. Functional analysis of genes which suffered damaging non-synonymous editing events in each cancer stage show the gradual expansion of cancer related pathways accompanied by an increasing malignant grade of the samples. Our study, for the first time to our knowledge, comprehensively profiled and compared the editomes across the different cancer stages and revealed the functional impacts of RNA editing events during cancer development and progression.
关键词	post-transcriptional regulation RNA editome tumorigenesis metastasis transcriptome
DOI	10.3389/fgene.2017.00230
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[3140111] ; National Natural Science Foundation of China[31371320] ; National Natural Science Foundation of China[61472397] ; National Natural Science Foundation of China[31501066]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000422693700001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/6250
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Luo, Haitao; Zhao, Yi
作者单位	1.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Luo, Haitao,Fang, Shuangsang,Sun, Liang,et al. Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression[J]. FRONTIERS IN GENETICS,2018,8:8.
APA	Luo, Haitao,Fang, Shuangsang,Sun, Liang,Liu, Zhiyong,&Zhao, Yi.(2018).Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression.FRONTIERS IN GENETICS,8,8.
MLA	Luo, Haitao,et al."Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression".FRONTIERS IN GENETICS 8(2018):8.