Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation

doi:10.1002/jcp.29132

	Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation
	Hong, Shuai 1; Hu, Supei 2; Kang, Zhengyang 3; Liu, Zhiguo 4; Yang, Weibin 4; Zhang, Yongzhi 4; Yang, Dengfeng 4; Ruan, Wenhui 4; Yu, Guoyong 4; Sun, Liang 1; Chen, Liang 2
	2019-09-04
发表期刊	JOURNAL OF CELLULAR PHYSIOLOGY
ISSN	0021-9541
页码	13
摘要	Adult human mesenchymal stem cells have the potential to differentiate into osteoblast, which plays crucial roles in bone regeneration and repair. Some transcriptional factors (TFs), such as BMP-2 and RUNX2, have been demonstrated to control the differentiation processes. It is important to discover more key regulators in osteoblast differentiation. Recently, some studies found long noncoding RNAs (lncRNAs) participating in osteoblast differentiation, such as MALAT1, DANCR, and ANCR. In this study, we performed a network-based computational analysis to investigate the lncRNA-messenger RNA (mRNA) crosstalks via integrating microRNA (miRNA)-RNA interactions, gene coexpression, and protein-protein interactions. First, multiple topology analyses were performed to osteoblast-differentiation-related lncRNA-mRNA network (ODLMN). Several lncRNAs with central topology structures were identified as key regulators. Results showed that these lncRNAs participated in osteoblast differentiation via phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase, and Ras signals. Previous studies have demonstrated that lncRNAs exert functions by involving in close modules. Second, after performing module searching in ODLMN, two functional modules were identified, which played crucial roles through involving in PI3K/protein kinase B, cyclic adenosine 3MODIFIER LETTER PRIME,5MODIFIER LETTER PRIME-monophosphate, and hypoxia-inducible factor 1 pathways. Third, a subset of core lncRNA-TF crosstalks that might form feedback loops to control the biological processes in osteoblast differentiation was identified. These core lncRNA-TF feedback loops showed more TF binding affinity than other lncRNAs. All these results can help us to uncover the molecular mechanism and provide new targets for bone regeneration and repair.
关键词	ceRNA feedback loops lncRNA osteoblast differentiation
DOI	10.1002/jcp.29132
收录类别	SCI
语种	英语
资助项目	Medical Scientific Research Foundation of Zhejiang Province, China[2015KYB342]
WOS研究方向	Cell Biology ; Physiology
WOS类目	Cell Biology ; Physiology
WOS记录号	WOS:000485028500001
出版者	WILEY
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/4694
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Yu, Guoyong; Sun, Liang; Chen, Liang
作者单位	1.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Ctr, Key Lab Intelligent Informat Proc, 6 Kexueyuan South Rd Zhongguancun, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Hwa Mei Hosp, Ningbo, Zhejiang, Peoples R China 3.Second Peoples Hosp Panyu, Dept Orthoped, Guangzhou, Guangdong, Peoples R China 4.Hanzhong Cent Hosp, Dept Osteoarthrit Trauma, Hanzhong, Peoples R China
推荐引用方式 GB/T 7714	Hong, Shuai,Hu, Supei,Kang, Zhengyang,et al. Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2019:13.
APA	Hong, Shuai.,Hu, Supei.,Kang, Zhengyang.,Liu, Zhiguo.,Yang, Weibin.,...&Chen, Liang.(2019).Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation.JOURNAL OF CELLULAR PHYSIOLOGY,13.
MLA	Hong, Shuai,et al."Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation".JOURNAL OF CELLULAR PHYSIOLOGY (2019):13.