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Cellular Responses to Exposure to Outdoor Air from the Chinese Spring Festival at the Air-Liquid Interface
Ding, Jie1,2,3,4; Guo, Jincheng5; Wang, Liming6; Chen, Yandong1,2,3,4; Hu, Bin1,2,3,4; Li, Yiye1,2,3,4; Huang, Rujin7; Cao, Junji7; Zhao, Yuliang1,2,3,4; Geiser, Marianne10; Miao, Qing8,9; Liu, Ying1,2,3,4; Chen, Chunying1,2,3,4
2019-08-06
发表期刊ENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
卷号53期号:15页码:9128-9138
摘要The Spring Festival is the most important holiday in China. During this time, the levels of particulate matter (PM) as well as gaseous copollutants significantly increase because of the widespread enjoyment of fireworks. The expression patterns of microRNAs may serve as valuable signatures of exposure to environmental constituents. We exposed macrophages to the whole stream of outdoor air at the air-liquid interface aiming at closely approximating the physiological conditions and the inhalation situation in the lung. 58 miRNAs were up-regulated, and 68 miRNAs were down-regulated in the night of the New Year's Eve (exposure group E2N1) compared to filtered-air exposed control cells. The target genes of the up-regulated miRNAs were enriched in immunity- and inflammation-linked pathways, such as the TLR-NF-kappa B pathway. Compared to the E2N1 group, 29 miRNAs were up-regulated, and 23 miRNAs were down-regulated in the cells exposed to air from the daytime of the Chinese New Year with higher concentrations of particles, SO2, and nitrogen oxide. The target genes of the up-regulated miRNAs were mostly enriched in apoptosis, adhesion, and junction-related pathways. These results preliminarily unravel part of the toxic mechanisms of air constituents and provide clues for discovering the main drivers of air pollution-induced disorders.
DOI10.1021/acs.est.9b00399
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[11435002] ; National Natural Science Foundation of China[91543206] ; National Natural Science Foundation of China[91543127] ; National Natural Science Foundation of China[31622026] ; National Basic Research Program of China[2016YFA0201600] ; National Basic Research Program of China[2016YFE0133100] ; National Basic Research Program of China[2017YFC1600204] ; National Basic Research Program of China[2016YFA0203204] ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China[11621505] ; CAS Key Research Program for Frontier Sciences[QYZDJ-SSW-SLH022] ; National Science Fund for Distinguished Young Scholars[11425520]
WOS研究方向Engineering ; Environmental Sciences & Ecology
WOS类目Engineering, Environmental ; Environmental Sciences
WOS记录号WOS:000480370600068
出版者AMER CHEMICAL SOC
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://119.78.100.204/handle/2XEOYT63/4457
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Miao, Qing; Liu, Ying; Chen, Chunying
作者单位1.CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
2.CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
3.Natl Ctr Nanosci & Technol China, Beijing Key Lab Ambient Particles Hlth Effects &, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
5.Chinese Acad Sci, CAS Key Lab Intelligent Informat Proc, Adv Comp Res Ctr, Inst Comp Technol, Beijing 100190, Peoples R China
6.Chinese Acad Sci, Inst High Energy Phys, Div Nucl Technol & Applicat, Beijing 100049, Peoples R China
7.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian 710061, Shaanxi, Peoples R China
8.Med Coll Wisconsin, Childrens Res Inst, Div Pediat Surg, Dept Surg, Milwaukee, WI 53226 USA
9.Med Coll Wisconsin, Childrens Res Inst, Div Pediat Pathol, Dept Pathol, Milwaukee, WI 53226 USA
10.Univ Bern, Inst Anat, CH-3012 Bern, Switzerland
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Ding, Jie,Guo, Jincheng,Wang, Liming,et al. Cellular Responses to Exposure to Outdoor Air from the Chinese Spring Festival at the Air-Liquid Interface[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(15):9128-9138.
APA Ding, Jie.,Guo, Jincheng.,Wang, Liming.,Chen, Yandong.,Hu, Bin.,...&Chen, Chunying.(2019).Cellular Responses to Exposure to Outdoor Air from the Chinese Spring Festival at the Air-Liquid Interface.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(15),9128-9138.
MLA Ding, Jie,et al."Cellular Responses to Exposure to Outdoor Air from the Chinese Spring Festival at the Air-Liquid Interface".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.15(2019):9128-9138.
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