An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body

doi:10.1111/cpr.12667

	An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body
	Li, Hongyi 1; Yang, Chongqing 1; Yin, Yajun 2; Wang, Fang 1; Chen, Min 1; Xu, Liang 1; Wang, Naili 3,4; Zhang, Di 3,4; Wang, Xiaoxia 1; Kong, Yiya 1; Li, Qing 1; Su, Si 3,4; Cao, Yupeng 5; Liu, Wentao 5; Ao, Zhuo 5; Dai, Luru 5; Ma, Chao 3,4; Shang, Lijun 6; Han, Dong 5; Ji, Fusui 1; Li, Hua 7
	2019-08-01
发表期刊	CELL PROLIFERATION
ISSN	0960-7722
页码	14
摘要	Objective Interstitial fluid in extracellular matrices may not be totally fixed but partially flow through long-distance oriented fibrous connective tissues via physical mechanisms. We hypothesized there is a long-distance interstitial fluid transport network beyond vascular circulations. Materials and methods We first used 20 volunteers to determine hypodermic entrant points to visualize long-distance extravascular pathway by MRI. We then investigated the extravascular pathways initiating from the point of thumb in cadavers by chest compressor. The distributions and structures of long-distance pathways from extremity ending to associated visceral structures were identified. Results Using fluorescent tracer, the pathways from right thumb to right atrium wall near chest were visualized in seven of 10 subjects. The cutaneous pathways were found in dermic, hypodermic and fascial tissues of hand and forearm. The perivascular pathways were along the veins of arm, axillary sheath, superior vena cava and into the superficial tissues on right atrium. Histological and micro-CT data showed these pathways were neither blood nor lymphatic vessels but long-distance oriented fibrous matrices, which contained the longitudinally assembled micro-scale fibres consistently from thumb to superficial tissues on right atrium. Conclusions These data revealed the structural framework of the fibrous extracellular matrices in oriented fibrous connective tissues was of the long-distance assembled fibres throughout human body. Along fibres, interstitial fluid can systemically transport by certain driving-transfer mechanisms beyond vascular circulations.
关键词	extracellular matrix fibrous connective tissues gross anatomy interfacial transport interstitial fluid
DOI	10.1111/cpr.12667
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[11672150] ; National Basic Research Program of China[2015CB554507] ; Beijing Hospital Clinical Research 121 Project[1212016002]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000479981100001
出版者	WILEY
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/4442
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Li, Hongyi; Yin, Yajun; Ji, Fusui
作者单位	1.Beijing Hosp, Natl Ctr Gerontol, Beijing, Peoples R China 2.Tsinghua Univ, Dept Engn Mech, Beijing, Peoples R China 3.Chinese Acad Med Sci, Neurosci Ctr, Inst Basic Med Sci, Dept Human Anat Histol & Embryol, Beijing, Peoples R China 4.Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China 5.Natl Ctr Nanosci & Technol, Beijing, Peoples R China 6.Univ Bradford, Sch Chem & Biosci, Bradford, W Yorkshire, England 7.Chinese Acad Sci, Inst Comp Technol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Hongyi,Yang, Chongqing,Yin, Yajun,et al. An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body[J]. CELL PROLIFERATION,2019:14.
APA	Li, Hongyi.,Yang, Chongqing.,Yin, Yajun.,Wang, Fang.,Chen, Min.,...&Li, Hua.(2019).An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body.CELL PROLIFERATION,14.
MLA	Li, Hongyi,et al."An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body".CELL PROLIFERATION (2019):14.