Robust projection parameter calibration in cryo-ET with<i> L</i>1-norm optimization

doi:10.1016/j.ultramic.2025.114134

	Robust projection parameter calibration in cryo-ET with L1-norm optimization
	Guo, Shengkai 1; Xu, Zihe 1; Li, Xinyan 1; Yang, Zhidong 2; Feng, Chenjie 3; Han, Renmin 1
	2025-08-01
发表期刊	ULTRAMICROSCOPY
ISSN	0304-3991
卷号	274 页码:10
摘要	Fiducial marker-based alignment in cryo-electron tomography (cryo-ET) has been extensively studied over a long period. The calibration of projection parameters using nonlinear least squares technique methodologies stands as the ultimate and pivotal stage in the alignment procedure. The efficacy of calibration is substantially impacted by noise and outliers in the marker data obtained from previous steps. Several robust fitting methods have been explored and implemented to address this issue by improving marker data or assigning weights to markers. However, these methods have their own limitations and often assume general Gaussian noise assumption, which may not accurately represent the distribution of noise and outliers in the marker data. In this work, we propose a robust projection parameter calibration model based on L1-norm optimization under Laplace noise assumption in order to overcome the limitations of existing methods. To efficiently solve the problem, we also design a faster and stabler first-order non-sparse method based on smooth approximation strategy. Additionally, we introduce subgradient and subdifferential for mathematical analysis. The accuracy, robustness, and efficacy of our approach are demonstrated through both simulated and real-world experiments.
关键词	Cryo-ET Fiducial marker-based alignment Smoothing approximation
DOI	10.1016/j.ultramic.2025.114134
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2021YFF0704300] ; Fundamental Research Funds for the Central Universities, China ; Natural Science Foundation of Ningxia Province, China[2023AAC05036] ; Natural Science Foundation of Ningxia Province, China[2024AAC03247] ; National Natural Science Foundation of China[61932018] ; Natural Science Foundation of Shandong Province[ZR2023YQ057] ; Instrument Improvement Funds of Shandong University Public Technology Platform[ts20230204] ; [2024YCZX0041] ; [32241027]
WOS研究方向	Microscopy
WOS类目	Microscopy
WOS记录号	WOS:001488087200001
出版者	ELSEVIER
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/42384
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Feng, Chenjie; Han, Renmin
作者单位	1.Shandong Univ, Frontiers Sci Ctr Nonlinear Expectat, Res Ctr Math & Interdisciplinary Sci, Minist Educ,Cheeloo Coll Med,Qilu Hosp Qingdao, Qingdao 266237, Peoples R China 2.Inst Comp Technol, CAS, High Performance Comp Res Ctr, Beijing 100190, Peoples R China 3.Ningxia Med Univ, Coll Med Informat & Engn, Yinchuan 750004, Peoples R China
推荐引用方式 GB/T 7714	Guo, Shengkai,Xu, Zihe,Li, Xinyan,et al. Robust projection parameter calibration in cryo-ET with L1-norm optimization[J]. ULTRAMICROSCOPY,2025,274:10.
APA	Guo, Shengkai,Xu, Zihe,Li, Xinyan,Yang, Zhidong,Feng, Chenjie,&Han, Renmin.(2025).Robust projection parameter calibration in cryo-ET with L1-norm optimization.ULTRAMICROSCOPY,274,10.
MLA	Guo, Shengkai,et al."Robust projection parameter calibration in cryo-ET with L1-norm optimization".ULTRAMICROSCOPY 274(2025):10.