6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda

doi:10.1038/s41467-019-10202-3

	6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
	He, Shunmin 1,2; Zhang, Guoqiang 1; Wang, Jiajia 2; Gao, Yajie 1,3; Sun, Ruidi 1,4; Cao, Zhijie 1; Chen, Zhenping 1; Zheng, Xiudeng 5; Yuan, Jiao 2; Luo, Yuewan 1,3; Wang, Xiaona 1; Zhang, Wenxin 1,4; Zhang, Peng 2; Zhao, Yi 6; He, Chuan 7,8; Tao, Yi 5; Sun, Qinmiao 1,3; Chen, Dahua 1,3
	2019-05-17
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	10 页码:14
摘要	A long-standing question in the field of embryogenesis is how the zygotic genome is precisely activated by maternal factors, allowing normal early embryonic development. We have previously shown that N6-methyladenine (6mA) DNA modification is highly dynamic in early Drosophila embryos and forms an epigenetic mark. However, little is known about how 6mA-formed epigenetic information is decoded. Here we report that the Fox-family protein Jumu binds 6mA-marked DNA and acts as a maternal factor to regulate the maternal-to-zygotic transition. We find that zelda encoding the pioneer factor Zelda is marked by 6mA. Our genetic assays suggest that Jumu controls the proper zygotic genome activation (ZGA) in early embryos, at least in part, by regulating zelda expression. Thus, our findings not only support that the 6mA-formed epigenetic marks can be read by specific transcription factors, but also uncover a mechanism by which the Jumu regulates ZGA partially through Zelda in early embryos.
DOI	10.1038/s41467-019-10202-3
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology of China[2016YFA0100400] ; Ministry of Science and Technology of China[2018YFC1003300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB13000000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000] ; Natural Science Foundation of China[31590831] ; Natural Science Foundation of China[31671498] ; Natural Science Foundation of China[31871294] ; National Key R&D Program of China[2017YFA0506800] ; National Key R&D Program of China[2016YFC0901700] ; CAS Interdisciplinary Innovation Team
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000468174600019
出版者	NATURE PUBLISHING GROUP
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/4226
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Sun, Qinmiao; Chen, Dahua
作者单位	1.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Ctr Big Data Res Hlth, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Sch Life Sci, Beijing 100049, Peoples R China 4.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Anhui, Peoples R China 5.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Ctr Computat & Evolutionary Biol, Beijing 100101, Peoples R China 6.Chinese Acad Sci, Adv Comp Res Ctr, Inst Comp Technol, Beijing 100190, Peoples R China 7.Univ Chicago, Howard Hughes Med Inst, Dept Chem, 5841 S Maryland Ave, Chicago, IL 60637 USA 8.Univ Chicago, Howard Hughes Med Inst, Inst Biophys Dynam, 5841 S Maryland Ave, Chicago, IL 60637 USA
推荐引用方式 GB/T 7714	He, Shunmin,Zhang, Guoqiang,Wang, Jiajia,et al. 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda[J]. NATURE COMMUNICATIONS,2019,10:14.
APA	He, Shunmin.,Zhang, Guoqiang.,Wang, Jiajia.,Gao, Yajie.,Sun, Ruidi.,...&Chen, Dahua.(2019).6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda.NATURE COMMUNICATIONS,10,14.
MLA	He, Shunmin,et al."6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda".NATURE COMMUNICATIONS 10(2019):14.