CircRNAwrap - a flexible pipeline for circRNA identification, transcript prediction, and abundance estimation

doi:10.1002/1873-3468.13423

	CircRNAwrap - a flexible pipeline for circRNA identification, transcript prediction, and abundance estimation
	Li, Lin 1; Bu, Dechao 2; Zhao, Yi 2
	2019-06-01
发表期刊	FEBS LETTERS
ISSN	0014-5793
卷号	593 期号:11 页码:1179-1189
摘要	Circular RNA (circRNA) is a recently described RNA molecule formed by backsplicing, with the 3 ' and 5 ' ends linked covalently. The study of circRNAs using RNA-Seq data enables the analysis of genome-wide endogenous circular transcripts. Although several algorithms for circRNA analysis have been developed, they have thus far had limited application. Additionally, approaches for prediction and validation of the composition of exons in circRNAs are still being developed. In this study, we measured the effectiveness of existing tools on collected and simulated data. Furthermore, we carried out a wide-ranging study of circRNA workflows, which we named circRNAwrap. Application of circRNAwrap on the included datasets reveals that our novel protocol can assist researchers in the study of circRNA biology.
关键词	abundance circRNA circRNAwrap detection transcript
DOI	10.1002/1873-3468.13423
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2018YFC1313000] ; National Key Research and Development Program of China[2018YFC1313001] ; National Natural Science Foundation for Young Scholars of China[31701141] ; National Natural Science Foundation for Young Scholars of China[31701149] ; National Natural Science Foundation for Young Scholars of China[31501066] ; National Natural Science Foundation of China[91740113] ; Innovation Project for Institute of Computing Technology, CAS[20186060]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号	WOS:000470956700005
出版者	WILEY
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/4188
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhao, Yi
作者单位	1.Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Comp Technol, Bioinformat Res Grp, Adv Comp Res Lab, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Lin,Bu, Dechao,Zhao, Yi. CircRNAwrap - a flexible pipeline for circRNA identification, transcript prediction, and abundance estimation[J]. FEBS LETTERS,2019,593(11):1179-1189.
APA	Li, Lin,Bu, Dechao,&Zhao, Yi.(2019).CircRNAwrap - a flexible pipeline for circRNA identification, transcript prediction, and abundance estimation.FEBS LETTERS,593(11),1179-1189.
MLA	Li, Lin,et al."CircRNAwrap - a flexible pipeline for circRNA identification, transcript prediction, and abundance estimation".FEBS LETTERS 593.11(2019):1179-1189.