MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma

doi:10.1038/s41419-025-07991-5

	MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma
	Du, Kaining 1,2; Zhang, Xiaojing 1,2,3; Qin, Ying 4; Ma, Huizhen 1; Bing, Chuhan 1; Deng, Shiqi 1,2; Chen, Yang 1,2; Qin, Jiequan 1; Chang, Shanshan 1,2; Xiao, Siyu 1; Peng, Lehua 1; Xie, Xiaoya 1; Feng, Xianling 1; Fu, Xianli 5; Wei, Yanjie 6; Fan, Xinmin 1; Ashktorab, Hassan 7; Smoot, Duane 8; Jin, Zhe 1,2; Peng, Yin 1,2
	2025-09-01
发表期刊	CELL DEATH & DISEASE
ISSN	2041-4889
卷号	16 期号:1 页码:17
摘要	Gastric cancer (GC) is one of the most common and lethal malignancies in developing countries, with particularly high prevalence in China. Circular RNAs (circRNAs) have garnered increasing attention for their roles in disease pathogenesis. While circRNAs can be translated, there have been few investigations into the biological functions of "translatable circRNAs" in the initiation and progression of gastric adenocarcinoma. In this study, we identified a circRNA, circMAP3K13, which inhibits the proliferation and migration of GC cells. CircMAP3K13 was found to encode a previously unreported 26 kDa protein, designated MAP3K13-232aa. Mechanistically, MAP3K13-232aa binds directly to the kinase domain of IKK alpha and enhances its activity, thereby promoting NF-kappa B signaling. This activation leads to upregulation of NLRP3 and increased cisplatin-induced pyroptosis in GC cells. Moreover, MAP3K13-232aa enhances pyroptosis and reduces tumorigenicity and metastasis in vivo. Taken together, both circMAP3K13 and its encoded protein MAP3K13-232aa represent potential therapeutic targets in GC.
DOI	10.1038/s41419-025-07991-5
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China (National Science Foundation of China) ; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:001561628600004
出版者	SPRINGERNATURE
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/41737
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Peng, Yin
作者单位	1.Shenzhen Univ Hlth Sci Ctr, Dept Pathol, Guangdong Prov Key Lab Genome Stabil & Dis Prevent, Shenzhen, Guangdong, Peoples R China 2.Shenzhen Univ, Shenzhen Univ Med Sch, Dept Pathol, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen, Guangdong, Peoples R China 3.Shenzhen Univ, Shenzhen Univ Med Sch, Dept Pathol, Guangdong Prov Key Lab Mol Oncol Pathol, Shenzhen, Guangdong, Peoples R China 4.Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Gastrointestinal Surg, Shenzhen, Guangdong, Peoples R China 5.Shenzhen Univ Gen Hosp, Dept Pathol, Shenzhen, Guangdong, Peoples R China 6.Shenzhen Inst Adv Technol, Ctr High Performance Comp, Shenzhen, Guangdong, Peoples R China 7.Howard Univ, Coll Med, Dept Med & Canc Ctr, Washington, DC USA 8.Meharry Med Ctr, Dept Med, Nashville, TN USA
推荐引用方式 GB/T 7714	Du, Kaining,Zhang, Xiaojing,Qin, Ying,et al. MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma[J]. CELL DEATH & DISEASE,2025,16(1):17.
APA	Du, Kaining.,Zhang, Xiaojing.,Qin, Ying.,Ma, Huizhen.,Bing, Chuhan.,...&Peng, Yin.(2025).MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma.CELL DEATH & DISEASE,16(1),17.
MLA	Du, Kaining,et al."MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma".CELL DEATH & DISEASE 16.1(2025):17.