SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping

doi:10.1093/nar/gky1021

	SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping
	Wu, Yang 1,2; Zhang, Feilong 1; Yang, Kuo 3,4; Fang, Shuangsang 2; Bu, Dechao 2; Li, Hui 2; Sun, Liang 2; Hu, Hairuo 2; Gao, Kuo 1; Wang, Wei 1; Zhou, Xuezhong 3,4; Zhao, Yi 1,2; Chen, Jianxin 1
	2019-01-08
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	47 期号:D1 页码:D1110-D1117
摘要	Recently, the pharmaceutical industry has heavily emphasized phenotypic drug discovery (PDD), which relies primarily on knowledge about phenotype changes associated with diseases. Traditional Chinese medicine (TCM) provides a massive amount of information on natural products and the clinical symptoms they are used to treat, which are the observable disease phenotypes that are crucial for clinical diagnosis and treatment. Curating knowledge of TCM symptoms and their relationships to herbs and diseases will provide both candidate leads and screening directions for evidence-based PDD programs. Therefore, we present SymMap, an integrative database of traditional Chinese medicine enhanced by symptom mapping. We manually curated 1717 TCM symptoms and related them to 499 herbs and 961 symptoms used in modern medicine based on a committee of 17 leading experts practicing TCM. Next, we collected 5235 diseases associated with these symptoms, 19 595 herbal constituents (ingredients) and 4302 target genes, and built a large heterogeneous network containing all of these components. Thus, SymMap integrates TCM with modern medicine in common aspects at both the phenotypic and molecular levels. Furthermore, we inferred all pairwise relationships among SymMap components using statistical tests to give pharmaceutical scientists the ability to rank and filter promising results to guide drug discovery. The SymMap database can be accessed at http://www.symmap.org/ and https://www.bioinfo.org/symmap.
DOI	10.1093/nar/gky1021
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2018YFC1313000] ; National Key Research and Development Program of China[2018YFC1313001] ; National Key Research and Development Program of China[2017YFC1703506] ; National Natural Science Foundation for Young Scholars of China[31701141] ; National Natural Science Foundation for Young Scholars of China[31701149] ; National Natural Science Foundation for Young Scholars of China[31501066] ; National Natural Science Foundation of China[91740113] ; National Natural Science Foundation of China[81522051] ; Innovation Project for Institute of Computing Technology, CAS[20186060]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000462587400152
出版者	OXFORD UNIV PRESS
引用统计	被引频次：305[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/4156
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhou, Xuezhong; Zhao, Yi; Chen, Jianxin
作者单位	1.Beijing Univ Chinese Med, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Ctr, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China 3.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Beijing 100044, Peoples R China 4.Beijing Jiaotong Univ, Beijing Key Lab Traff Data Anal & Min, Beijing 100044, Peoples R China
推荐引用方式 GB/T 7714	Wu, Yang,Zhang, Feilong,Yang, Kuo,et al. SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping[J]. NUCLEIC ACIDS RESEARCH,2019,47(D1):D1110-D1117.
APA	Wu, Yang.,Zhang, Feilong.,Yang, Kuo.,Fang, Shuangsang.,Bu, Dechao.,...&Chen, Jianxin.(2019).SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping.NUCLEIC ACIDS RESEARCH,47(D1),D1110-D1117.
MLA	Wu, Yang,et al."SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping".NUCLEIC ACIDS RESEARCH 47.D1(2019):D1110-D1117.