From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research

doi:10.1097/CM9.0000000000003535

	From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research
	Liu, Kailun 1,2; Chen, Xiaowei 3; Fan, Zhen 3; Ren, Fei 4; Liu, Jing 1,2; Hu, Baoyang 1,2,5
	2025-04-05
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	138 期号:7 页码:792-807
摘要	The high failure rates in clinical drug development based on animal models highlight the urgent need for more representative human models in biomedical research. In response to this demand, organoids and organ chips were integrated for greater physiological relevance and dynamic, controlled experimental conditions. This innovative platform-the organoids-on-a-chip technology-shows great promise in disease modeling, drug discovery, and personalized medicine, attracting interest from researchers, clinicians, regulatory authorities, and industry stakeholders. This review traces the evolution from organoids to organoids-on-a-chip, driven by the necessity for advanced biological models. We summarize the applications of organoids-on-a-chip in simulating physiological and pathological phenotypes and therapeutic evaluation of this technology. This section highlights how integrating technologies from organ chips, such as microfluidic systems, mechanical stimulation, and sensor integration, optimizes organoid cell types, spatial structure, and physiological functions, thereby expanding their biomedical applications. We conclude by addressing the current challenges in the development of organoids-on-a-chip and offering insights into the prospects. The advancement of organoids-on-a-chip is poised to enhance fidelity, standardization, and scalability. Furthermore, the integration of cutting-edge technologies and interdisciplinary collaborations will be crucial for the progression of organoids-on-a-chip technology.
关键词	Organoids-on-a-chip Organoids Organ-on-a-chip Drug testing Disease modeling
DOI	10.1097/CM9.0000000000003535
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2024YFA1108302] ; National Key Research and Development Program of China[2021YFA1101400] ; Strategic Priority Research Program of CAS[XDA 0460205] ; Open Project of Key Laboratory of Organ Regeneration and Intelligent Manufacturing[2024KF31] ; Basic Frontier Science Research Program of CAS[ZDBS-LY-SM024]
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
WOS记录号	WOS:001460594600002
出版者	LIPPINCOTT WILLIAMS & WILKINS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/40669
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Ren, Fei; Liu, Jing; Hu, Baoyang
作者单位	1.Chinese Acad Sci, State Key Lab Stem Cell & Reprod Biol, Inst Zool, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Zool, Key Lab Organ Regenerat & Reconstruct, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Comp Technol, State Key Lab Processors, Beijing 100190, Peoples R China 5.Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Liu, Kailun,Chen, Xiaowei,Fan, Zhen,et al. From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research[J]. CHINESE MEDICAL JOURNAL,2025,138(7):792-807.
APA	Liu, Kailun,Chen, Xiaowei,Fan, Zhen,Ren, Fei,Liu, Jing,&Hu, Baoyang.(2025).From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research.CHINESE MEDICAL JOURNAL,138(7),792-807.
MLA	Liu, Kailun,et al."From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research".CHINESE MEDICAL JOURNAL 138.7(2025):792-807.