Free water alterations in different inflammatory subgroups in schizophrenia

doi:10.1016/j.bbi.2023.11.006

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	Free water alterations in different inflammatory subgroups in schizophrenia
	Wu, Dongsheng 1,2,3; Wu, Qi 4; Li, Fei 5,6; Wang, Yaxuan 5,6; Zeng, Jiaxin 5,6; Tang, Biqiu 5,6; Bishop, Jeffrey R.7,8; Xiao, Li 4,9,11; Lui, Su 5,6,10
	2024
发表期刊	BRAIN BEHAVIOR AND IMMUNITY
ISSN	0889-1591
卷号	115 页码:557-564
摘要	Background: Accumulating evidence suggests that inflammatory dysregulation both in blood and the brain is implicated in the pathogenesis of schizophrenia. Alterations in peripheral cytokines are not evident in all patients and there may be discrete altered inflammatory subgroups in schizophrenia. Recent studies using a novel and in vivo free-water imaging to detect inflammatory processes, have shown increased free water in white matter in schizophrenia. However, no studies to date have investigated the free water alterations in different inflammatory subgroups in schizophrenia.Methods: Forty-four patients with schizophrenia and 49 controls were recruited. The serum levels of interleukin-1 beta (IL-113), IL-6, IL-10, and IL-12p70 were measured and used for cluster analysis with K-means and hierarchical algorithms. Diffusion tensor imaging (DTI) images were collected for all participants and voxel-wise free water and fractional anisotropy of tissue (FA-t) were compared between groups with Randomise running in FSL. Partial correlation analysis was employed to explore the association of the peripheral cytokine levels with free water.Results: We identified two statistically quantifiable discrete subgroups of patients based on the cluster analysis of cytokine measures. The peripheral levels of IL-113 (P < 0.001), IL-10 (P = 0.041), and IL-12p70 (P < 0.001) showed significant differences between the two different inflammatory subgroups. In the inflammatory subgroup with a predominantly higher IL-113 level, increased free water values in white matter were found mainly in the left posterior limb of the internal capsule, posterior corona radiata, and partly in the left sagittal stratum. These affected areas did not overlap with the regions that showed significant free water differences between patients and healthy controls. In the inflammatory subgroup with lower IL-113 levels, peripheral IL-113 was significantly associated with free water values in white matter while no such association was detected in the patient group.Conclusions: Localized free water differences were demonstrated between the two identified inflammatory subgroups in our data, and free water appears to be a feasible in vivo neuroimaging biomarker guiding the target of inflammatory intervention and development of new therapeutic strategies in an individualized manner in schizophrenia.
关键词	Diffusion tension imaging Free water Inflammation Cluster analysis Schizophrenia
DOI	10.1016/j.bbi.2023.11.006
收录类别	SCI
语种	英语
资助项目	Humboldt Foundation Friedrich Wilhelm Bessel Research Award ; Chang Jiang Scholars[T2019069] ; Fundamental Research Funds for the Central Universities[2023RC09] ; National Natural Science Foundation of China[82120108014] ; National Natural Science Foundation of China[82071908] ; National Key Research and Development Program of China[2022YFC2009901] ; National Key Research and Development Program of China[2022YFC2009900] ; CAMS Innovation Fund for Medical Sciences (CIFMS)[2021-I2M-C] ; CAMS Innovation Fund for Medical Sciences (CIFMS)[T-A-022] ; Sichuan Science and Technology Program[2021JDTD0002] ; Sichuan Science and Technology Program[2023NSFSC0651]
WOS研究方向	Immunology ; Neurosciences & Neurology ; Psychiatry
WOS类目	Immunology ; Neurosciences ; Psychiatry
WOS记录号	WOS:001125318100001
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/38484
专题	中国科学院计算技术研究所
通讯作者	Xiao, Li; Lui, Su
作者单位	1.Sichuan Univ, West China Sch Publ Hlth, Dept Radiol, Chengdu, Sichuan, Peoples R China 2.Sichuan Univ, West China Hosp 4, Chengdu, Sichuan, Peoples R China 3.Sichuan Univ, West China PUMC C C Chen Inst Hlth, Chengdu, Sichuan, Peoples R China 4.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing, Peoples R China 5.Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol,West China Hosp, Funct & Mol Imaging Key Lab Sichuan Prov, Chengdu, Peoples R China 6.Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu, Sichuan, Peoples R China 7.Univ Minnesota, Dept Expt & Clin Pharmacol, Minneapolis, MN USA 8.Univ Minnesota, Dept Psychiat & Behav Sci, Minneapolis, MN USA 9.Beijing Univ Posts & Telecommun, Sch Artificial Intelligence, Beijing, Peoples R China 10.Sichuan Univ, West China Hosp, Ctr Med Imaging, Dept Radiol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China 11.Beijing Univ Posts & Telecommun, Sch Artificial Intelligence, 10 Xitucheng Rd, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wu, Dongsheng,Wu, Qi,Li, Fei,et al. Free water alterations in different inflammatory subgroups in schizophrenia[J]. BRAIN BEHAVIOR AND IMMUNITY,2024,115:557-564.
APA	Wu, Dongsheng.,Wu, Qi.,Li, Fei.,Wang, Yaxuan.,Zeng, Jiaxin.,...&Lui, Su.(2024).Free water alterations in different inflammatory subgroups in schizophrenia.BRAIN BEHAVIOR AND IMMUNITY,115,557-564.
MLA	Wu, Dongsheng,et al."Free water alterations in different inflammatory subgroups in schizophrenia".BRAIN BEHAVIOR AND IMMUNITY 115(2024):557-564.