Association between gaming disorder and regional homogeneity in highly involved male adult gamers: A pilot resting-state fMRI study

doi:10.1002/brb3.3315

	Association between gaming disorder and regional homogeneity in highly involved male adult gamers: A pilot resting-state fMRI study
	Jiang, Wen-tao 1; Liu, Xia 1; Xu, Zi-yun 1; Zhou, Zhi-feng 1; Tie, Chang-jun 2,3; Liu, Xiao-ying 4; Yang, Ji-hui 4; Li, Hai 5; Lai, Wen-tao 1
	2023-11-06
发表期刊	BRAIN AND BEHAVIOR
ISSN	2162-3279
页码	12
摘要	BackgroundGaming behavior can induce cerebral changes that may be related to the neurobiological features of gaming disorder (GD). Additionally, individuals with higher levels of depression or impulsivity are more likely to experience GD. Therefore, the present pilot study explored potential neurobiological correlates of GD in the context of depression and impulsivity, after accounting for video gaming behavior.MethodsUsing resting-state functional magnetic resonance imaging (fMRI), a cross-sectional study was conducted with 35 highly involved male adult gamers to examine potential associations between GD severity and regional homogeneity (ReHo) in the entire brain. A mediation model was used to test the role of ReHo in the possible links between depression/impulsivity and GD severity.ResultsIndividuals with greater GD severity showed increased ReHo in the right Heschl's gyrus and decreased ReHo in the right hippocampus (rHip). Furthermore, depression and impulsivity were negatively correlated with ReHo in the rHip, respectively. More importantly, ReHo in the rHip was found to mediate the associations between depression/impulsivity and GD.ConclusionsThese preliminary findings suggest that GD severity is related to ReHo in brain regions associated with learning/memory/mood and auditory function. Higher levels of depression or impulsivity may potentiate GD through the functional activity of the hippocampus. Our findings advance our understanding of the neurobiological differences behind GD symptoms in highly involved gamers. 35 highly involved male adult gamers participated in this pilot study. Hippocampal dysfunction related to the gaming disorder severity, depression and impulsivity. Hippocampal dysfunction may play a critical role in the development of gaming disorder.image
关键词	depression gaming disorder highly involved gamers hippocampus impulsivity regional homogeneity
DOI	10.1002/brb3.3315
收录类别	SCI
语种	英语
资助项目	We would like to acknowledge Ping Ren for his revision of the manuscript and Xin-hui Xie for his suggestion for the study.
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
WOS记录号	WOS:001095185900001
出版者	WILEY
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/38110
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Liu, Xia; Lai, Wen-tao
作者单位	1.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Radiol, Shenzhen, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Comp Technol, Beijing, Peoples R China 3.Peng Cheng Lab, Shenzhen, Guangdong, Peoples R China 4.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Drug Dependence, Shenzhen, Guangdong, Peoples R China 5.Beijing Intelligent Brain Cloud Inc, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Wen-tao,Liu, Xia,Xu, Zi-yun,et al. Association between gaming disorder and regional homogeneity in highly involved male adult gamers: A pilot resting-state fMRI study[J]. BRAIN AND BEHAVIOR,2023:12.
APA	Jiang, Wen-tao.,Liu, Xia.,Xu, Zi-yun.,Zhou, Zhi-feng.,Tie, Chang-jun.,...&Lai, Wen-tao.(2023).Association between gaming disorder and regional homogeneity in highly involved male adult gamers: A pilot resting-state fMRI study.BRAIN AND BEHAVIOR,12.
MLA	Jiang, Wen-tao,et al."Association between gaming disorder and regional homogeneity in highly involved male adult gamers: A pilot resting-state fMRI study".BRAIN AND BEHAVIOR (2023):12.