Towards interpretable imaging genomics analysis: Methodological developments and applications

doi:10.1016/j.inffus.2023.102032

	Towards interpretable imaging genomics analysis: Methodological developments and applications
	Cen, Xiaoping 1,2,3; Dong, Wei 3,5,14; Lv, Wei 1,3; Zhao, Yi 7; Dubee, Fred 6; Mentis, Alexios-Fotios A.5; Jovic, Dragomirka 6; Yang, Huanming 1,3,4,15; Li, Yixue 2,8,9,10,11,12,13
	2024-02-01
发表期刊	INFORMATION FUSION
ISSN	1566-2535
卷号	102 页码:18
摘要	Identifying the relationship between imaging features and genetic variation (a term coined"imaging genomics") offers valuable insight into the pathogenesis of cancer, as well as cognitive and psychiatric disorders. However, how to integrate-omics and imaging data in a biologically meaningful approach to both provide pathobiological underpinning and achieve clinical applications remain challenging. In this review, we aim to discuss the difficulties in combining different sources of data and explaining the genotype-phenotype association, and we attempt to discuss the potential applications of imaging genomics in several (patho)physiological questions to better understand human physiology and disease. Future efforts on deciphering the genotype-phenotype landscapes by interpretable imaging genomics analyses are needed to provide new insights into molecular biology and molecular medicine.
关键词	Interpretability Imaging genomics Genotype -phenotype association Precision medicine
DOI	10.1016/j.inffus.2023.102032
收录类别	SCI
语种	英语
资助项目	CAS Research Fund[XDB38050200] ; Self-supporting Program of Guangzhou Laboratory[SRPG22-001] ; Self-supporting Program of Guangzhou Laboratory[SRPG22-007]
WOS研究方向	Computer Science
WOS类目	Computer Science, Artificial Intelligence ; Computer Science, Theory & Methods
WOS记录号	WOS:001083203700001
出版者	ELSEVIER
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/21114
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Yang, Huanming; Li, Yixue
作者单位	1.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 2.Guangzhou Int Bio Isl, Guangzhou Lab, 9 XingDaoHuanBei Rd, Guangzhou 510005, Peoples R China 3.Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, HIM BGI Om Ctr, Hangzhou 310022, Peoples R China 4.BGI China, Shenzhen 518083, Peoples R China 5.BGI Res, Shenzhen 518083, Peoples R China 6.BGI Res, Qingdao Europe Adv Inst Life Sci, Lars Bolund Inst Regenerat Med, Qingdao 266555, Peoples R China 7.Chinese Acad Sci, Inst Comp Technol, Res Ctr Ubiquitous Comp Syst, Beijing 100190, Peoples R China 8.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China 9.Guangzhou Med Univ, GMU GIBH Joint Sch Life Sci, Guangdong Hong Kong Macao Joint Lab Cell Fate Regu, Hong Kong 510120, Peoples R China 10.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China 11.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai 200030, Peoples R China 12.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China 13.Shanghai Inst Biomed & Pharmaceut Technol, Shanghai 200032, Peoples R China 14.BGI Genom, Clin Lab, Beijing 100000, Peoples R China 15.James D Watson Inst Genome Sci, Hangzhou 310029, Peoples R China
推荐引用方式 GB/T 7714	Cen, Xiaoping,Dong, Wei,Lv, Wei,et al. Towards interpretable imaging genomics analysis: Methodological developments and applications[J]. INFORMATION FUSION,2024,102:18.
APA	Cen, Xiaoping.,Dong, Wei.,Lv, Wei.,Zhao, Yi.,Dubee, Fred.,...&Li, Yixue.(2024).Towards interpretable imaging genomics analysis: Methodological developments and applications.INFORMATION FUSION,102,18.
MLA	Cen, Xiaoping,et al."Towards interpretable imaging genomics analysis: Methodological developments and applications".INFORMATION FUSION 102(2024):18.