Cross Analysis of Genomic-Pathologic Features on Multiple Primary Hepatocellular Carcinoma

doi:10.3389/fgene.2022.846517

	Cross Analysis of Genomic-Pathologic Features on Multiple Primary Hepatocellular Carcinoma
	Ren, Fei 1; Wang, Depin 1; Zhang, Xueyuan 1,2; Zhao, Na 2; Wang, Xiaowen 2; Zhang, Yu 3; Li, Li 4
	2022-06-20
发表期刊	FRONTIERS IN GENETICS
卷号	13 页码:9
摘要	Hepatocellular carcinoma (HCC) is a prevalent malignancy cancer worldwide with a poor prognosis. Hepatic resection is indicated as a potentially curative option for HCC patients in the early stage. However, due to multiple nodules, it leads to clinical challenges for surgical management. Approximately 41%-75% of HCC cases are multifocal at initial diagnosis, which may arise from multicentric occurrence (MO-HCC) or intrahepatic metastasis (IM-HCC) pattern with significantly different clinical outcomes. Effectively differentiating the two mechanisms is crucial to prioritize the allocation of surgery for multifocal HCC. In this study, we collected a multifocal hepatocellular carcinoma cohort of 17 patients with a total of 34 samples. We performed whole-exome sequencing and staining of pathological HE sections for each lesion. Reconstruction of the clonal evolutionary pattern using genome mutations showed that the intrahepatic metastogenesis pattern had a poorer survival performance than independent origins, with variants in the TP53, ARID1A, and higher CNV variants occurring more significantly in the metastatic pattern. Cross-modality analysis with pathology showed that molecular classification results were consistent with pathology results in 70.6% of patients, and we found that pathology results could further complement the classification for undefined patterns of occurrence. Based on these results, we propose a model to differentiate the pattern of multifocal hepatocellular carcinoma based on the pathological results and genome mutations information, which can provide guidelines for diagnosing and treating multifocal hepatocellular carcinoma.
关键词	hepatocellular carcinoma whole exome sequencing whole slide images molecular profiling and subtyping hepatitis B virus
DOI	10.3389/fgene.2022.846517
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2021YFF1201005] ; Beijing Xisike Clinical Oncology Research Foundation[Y-HS2019-33] ; Beijing Xisike Clinical Oncology Research Foundation[Y-BMS2019-015] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16021400] ; Informatization Plan of Chinese Academy of Sciences[CAS-WX2021SF-0101]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000890946500001
出版者	FRONTIERS MEDIA SA
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/20252
专题	中国科学院计算技术研究所期刊论文
通讯作者	Zhang, Yu; Li, Li
作者单位	1.Chinese Acad Sci, High Performance Comp Res Ctr, Inst Comp Technol, Beijing, Peoples R China 2.Zhijian Life Co Ltd, Beijing, Peoples R China 3.Peking Univ Third Hosp, Dept Med Oncol & Radiat Sickness, Beijing, Peoples R China 4.Peking Univ Int Hosp, Dept Oncol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Ren, Fei,Wang, Depin,Zhang, Xueyuan,et al. Cross Analysis of Genomic-Pathologic Features on Multiple Primary Hepatocellular Carcinoma[J]. FRONTIERS IN GENETICS,2022,13:9.
APA	Ren, Fei.,Wang, Depin.,Zhang, Xueyuan.,Zhao, Na.,Wang, Xiaowen.,...&Li, Li.(2022).Cross Analysis of Genomic-Pathologic Features on Multiple Primary Hepatocellular Carcinoma.FRONTIERS IN GENETICS,13,9.
MLA	Ren, Fei,et al."Cross Analysis of Genomic-Pathologic Features on Multiple Primary Hepatocellular Carcinoma".FRONTIERS IN GENETICS 13(2022):9.