NPInter v5.0: ncRNA interaction database in a new era

doi:10.1093/nar/gkac1002

	NPInter v5.0: ncRNA interaction database in a new era
	Zheng, Yu 1,2; Luo, Huaxia 1; Teng, Xueyi 1; Hao, Xinpei 1,3; Yan, Xiaoyu 1,3; Tang, Yiheng 1; Zhang, Wanyu 1; Wang, Yuanxin 1,3; Zhang, Peng 1; Li, Yanyan 1; Zhao, Yi 4; Chen, Runsheng 1; He, Shunmin 1,3
	2022-11-14
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
页码	8
摘要	Noncoding RNAs (ncRNAs) play key regulatory roles in biological processes by interacting with other biomolecules. With the development of high-throughput sequencing and experimental technologies, extensive ncRNA interactions have been accumulated. Therefore, we updated the NPInter database to a fifth version to document these interactions. ncRNA interaction entries were doubled from 1 100 618 to 2 596 695 by manual literature mining and high-throughput data processing. We integrated global RNA-DNA interactions from iMARGI, ChAR-seq and GRID-seq, greatly expanding the number of RNA-DNA interactions (from 888 915 to 8 329 382). In addition, we collected different types of RNA interaction between SARS-CoV-2 virus and its host from recently published studies. Long noncoding RNA (lncRNA) expression specificity in different cell types from tumor single cell RNA-seq (scRNA-seq) data were also integrated to provide a cell-type level view of interactions. A new module named RBP was built to display the interactions of RNA-binding proteins with annotations of localization, binding domains and functions. In conclusion, NPInter v5.0 (http://bigdata.ibp.ac.cn/npinter5/) provides informative and valuable ncRNA interactions for biological researchers.
DOI	10.1093/nar/gkac1002
收录类别	SCI
语种	英语
资助项目	Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000886006100001
出版者	OXFORD UNIV PRESS
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/19830
专题	中国科学院计算技术研究所期刊论文
通讯作者	Chen, Runsheng; He, Shunmin
作者单位	1.Chinese Acad Sci, Inst Biophys, Ctr Big Data Res Hlth, Key Lab RNA Biol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Ctr, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Yu,Luo, Huaxia,Teng, Xueyi,et al. NPInter v5.0: ncRNA interaction database in a new era[J]. NUCLEIC ACIDS RESEARCH,2022:8.
APA	Zheng, Yu.,Luo, Huaxia.,Teng, Xueyi.,Hao, Xinpei.,Yan, Xiaoyu.,...&He, Shunmin.(2022).NPInter v5.0: ncRNA interaction database in a new era.NUCLEIC ACIDS RESEARCH,8.
MLA	Zheng, Yu,et al."NPInter v5.0: ncRNA interaction database in a new era".NUCLEIC ACIDS RESEARCH (2022):8.