Identifying the miRNA Signature Association with Aging-Related Senescence in Glioblastoma

doi:10.3390/ijms22020517

	Identifying the miRNA Signature Association with Aging-Related Senescence in Glioblastoma
	Gnanavel, Mutharasu 1; Murugesan, Akshaya 1,2,3; Konda Mani, Saravanan 4; Yli-Harja, Olli 1,5,6; Kandhavelu, Meenakshisundaram 1,2,7
	2021
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	22 期号:2 页码:14
摘要	Glioblastoma (GBM) is the most common malignant brain tumor and its malignant phenotypic characteristics are classified as grade IV tumors. Molecular interactions, such as protein-protein, protein-ncRNA, and protein-peptide interactions are crucial to transfer the signaling communications in cellular signaling pathways. Evidences suggest that signaling pathways of stem cells are also activated, which helps the propagation of GBM. Hence, it is important to identify a common signaling pathway that could be visible from multiple GBM gene expression data. microRNA signaling is considered important in GBM signaling, which needs further validation. We performed a high-throughput analysis using micro array expression profiles from 574 samples to explore the role of non-coding RNAs in the disease progression and unique signaling communication in GBM. A series of computational methods involving miRNA expression, gene ontology (GO) based gene enrichment, pathway mapping, and annotation from metabolic pathways databases, and network analysis were used for the analysis. Our study revealed the physiological roles of many known and novel miRNAs in cancer signaling, especially concerning signaling in cancer progression and proliferation. Overall, the results revealed a strong connection with stress induced senescence, significant miRNA targets for cell cycle arrest, and many common signaling pathways to GBM in the network.
关键词	glioblastoma microRNA senescence molecular signaling biochemical pathways
DOI	10.3390/ijms22020517
收录类别	SCI
语种	英语
资助项目	Center for International Mobility (CIMO) Finland[TM-13-8898] ; Center for International Mobility (CIMO) Finland[KM-14-9107] ; Center for International Mobility (CIMO) Finland[TM-15-9720] ; Finnish cultural foundation[0116947-3] ; ICMR-DHR fellowship program
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000611310800001
出版者	MDPI
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/16307
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Kandhavelu, Meenakshisundaram
作者单位	1.Tampere Univ, Fac Med & Hlth Technol, BioMediTech Inst, ArvoYlponkatu 34, Tampere 33520, Finland 2.Tampere Univ, Fac Med & Hlth Technol, Mol Signalling Lab, POB 553, Tampere 33101, Finland 3.Lady Doak Coll, Dept Biotechnol, Madurai 625002, Tamil Nadu, India 4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr High Performance Comp, Shenzhen 518055, Peoples R China 5.Tampere Univ, Fac Med & Hlth Technol, Computat Syst Biol Grp, POB 553, Tampere 33101, Finland 6.Inst Syst Biol, 1441N 34th St, Seattle, WA 98109 USA 7.Tampere Univ Hosp, Sci Ctr, ArvoYlponkatu 34, Tampere 33520, Finland
推荐引用方式 GB/T 7714	Gnanavel, Mutharasu,Murugesan, Akshaya,Konda Mani, Saravanan,et al. Identifying the miRNA Signature Association with Aging-Related Senescence in Glioblastoma[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2021,22(2):14.
APA	Gnanavel, Mutharasu,Murugesan, Akshaya,Konda Mani, Saravanan,Yli-Harja, Olli,&Kandhavelu, Meenakshisundaram.(2021).Identifying the miRNA Signature Association with Aging-Related Senescence in Glioblastoma.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,22(2),14.
MLA	Gnanavel, Mutharasu,et al."Identifying the miRNA Signature Association with Aging-Related Senescence in Glioblastoma".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22.2(2021):14.