miRNA-192 and-215 activate Wnt/beta-catenin signaling pathway in gastric cancer via APC

doi:10.1002/jcp.29550

	miRNA-192 and-215 activate Wnt/beta-catenin signaling pathway in gastric cancer via APC
	Deng, Shiqi 1; Zhang, Xiaojing 1,2,3; Qin, Ying 4; Chen, Wangchun 1; Fan, Hu 1; Feng, Xianling 1; Wang, Jian 5; Yan, Ruibin 6; Zhao, Yanqiu 6; Cheng, Yulan 7,8; Wei, Yanjie 9; Fan, Xinmin 1; Ashktorab, Hassan 10,11; Smoot, Duane 12; Meltzer, Stephen J.7,8; Li, Song 6; Li, Kuan 1; Peng, Yin 1,2; Jin, Zhe 1,2
	2020-09-01
发表期刊	JOURNAL OF CELLULAR PHYSIOLOGY
ISSN	0021-9541
卷号	235 期号:9 页码:6218-6229
摘要	Although great progress has been made in surgical techniques, traditional radiotherapy, and chemotherapy, gastric cancer (GC) is still the most common malignant tumor and has a high mortality, which highlights the importance of novel diagnostic markers. Emerging studies suggest that different microRNAs (miRNAs) are involved in tumorigenesis of GC. In this study, we found that miRNA-192 and -215 are significantly upregulated in GC and promote cell proliferation and migration. Adenomatous polyposis coli (APC), a well-known negative regulator in Wnt signaling, has been proved to be a target of miRNA-192 and -215. Inhibition of miRNA-192 or -215 reduced the Topflash activities and repressed the expression of Wnt signaling pathway proteins, while APC small interfering RNAs reversed the inhibitory effects, suggesting that miRNA-192 and -215 activate Wnt signaling via APC. In addition, APC mediates the cell proliferation and migration regulated by miRNA-192 and -215. Furthermore, APC is downregulated in GC tissues and negatively correlated with the expression of miRNA-192 and -215. In summary, miRNA-192 and -215 target APC and function as oncogenic miRNAs by activating Wnt signaling in GC, revealing to be potential therapeutic targets.
关键词	APC gastric cancer miRNA-192 and-215 Wnt signaling pathway
DOI	10.1002/jcp.29550
收录类别	SCI
语种	英语
WOS研究方向	Cell Biology ; Physiology
WOS类目	Cell Biology ; Physiology
WOS记录号	WOS:000539325100028
出版者	WILEY
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/15206
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Peng, Yin; Jin, Zhe
作者单位	1.Shenzhen Univ, Dept Pathol, Sch Med, Guangdong Key Lab Genome Stabil & Dis Prevent, 3688 Nanhai Ave, Shenzhen 518060, Guangdong, Peoples R China 2.Shenzhen Univ, Dept Pathol, Hlth Sci Ctr, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen, Peoples R China 3.Dept Pathol, Guangdong Prov Key Lab Mol Oncol Pathol, Guangzhou, Guangdong, Peoples R China 4.Shenzhen Second Peoples Hosp, Dept Gastrointestinal Surg, Shenzhen, Guangdong, Peoples R China 5.Guangzhou Med Univ, Dept Pathol & Pathophysiol, Guangzhou, Peoples R China 6.Peking Univ, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen Grad Sch, Shenzhen, Guangdong, Peoples R China 7.Johns Hopkins Univ, Sch Med, Dept Med, GI Div, Baltimore, MD 21205 USA 8.Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA 9.Shenzhen Inst Adv Technol, Ctr High Performance Comp, Shenzhen, Guangdong, Peoples R China 10.Howard Univ, Dept Med, Washington, DC 20059 USA 11.Howard Univ, Coll Med, Ctr Canc, Washington, DC USA 12.Meharry Med Ctr, Dept Med, Nashville, TN USA
推荐引用方式 GB/T 7714	Deng, Shiqi,Zhang, Xiaojing,Qin, Ying,et al. miRNA-192 and-215 activate Wnt/beta-catenin signaling pathway in gastric cancer via APC[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2020,235(9):6218-6229.
APA	Deng, Shiqi.,Zhang, Xiaojing.,Qin, Ying.,Chen, Wangchun.,Fan, Hu.,...&Jin, Zhe.(2020).miRNA-192 and-215 activate Wnt/beta-catenin signaling pathway in gastric cancer via APC.JOURNAL OF CELLULAR PHYSIOLOGY,235(9),6218-6229.
MLA	Deng, Shiqi,et al."miRNA-192 and-215 activate Wnt/beta-catenin signaling pathway in gastric cancer via APC".JOURNAL OF CELLULAR PHYSIOLOGY 235.9(2020):6218-6229.