Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body

doi:10.1111/cpr.12760

	Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body
	Li, Hongyi 1; Yin, Yajun 2; Yang, Chongqing 1; Chen, Min 1; Wang, Fang 1; Ma, Chao 3,4; Li, Hua 5; Kong, Yiya 1; Ji, Fusui 1; Hu, Jun 6,7
	2020-01-19
发表期刊	CELL PROLIFERATION
ISSN	0960-7722
页码	8
摘要	Fluid in interstitial spaces accounts for similar to 20% of an adult body weight and flows diffusively for a short range. Does it circulate around the body like vascular circulations? This bold conjecture has been debated for decades. As a conventional physiological concept, interstitial space is a micron-sized space between cells and vasculature. Fluid in interstitial spaces is thought to be entrapped within interstitial matrix. However, our serial data have further defined a second space in interstitium that is a nanosized interfacial transport zone on a solid surface. Within this fine space, fluid along a solid fibre can be transported under a driving power and identically, interstitial fluid transport can be visualized by tracking the oriented fibres. Since 2006, our data from volunteers and cadavers have revealed a long-distance extravascular pathway for interstitial fluid flow, comprising at least four types of anatomic distributions. The framework of each extravascular pathway contains the longitudinally assembled and oriented fibres, working as a fibrorail for fluid flow. Interestingly, our data showed that the movement of fluid in a fibrous pathway is in response to a dynamic driving source and named as dynamotaxis. By analysis of previous studies and our experimental results, a hypothesis of interstitial fluid circulatory system is proposed.
关键词	extracellular matrix interstitial fluid interstitium vascular circulations
DOI	10.1111/cpr.12760
收录类别	SCI
语种	英语
资助项目	Beijing Hospital Clinical Research 121 Project[1212016002] ; National Natural Science Foundation of China[31350002] ; National Natural Science Foundation of China[11672150]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000508061600001
出版者	WILEY
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/15019
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Li, Hongyi
作者单位	1.Natl Ctr Gerontol, Beijing Hosp, Beijing, Peoples R China 2.Tsinghua Univ, Dept Engn Mech, Beijing, Peoples R China 3.Chinese Acad Med Sci, Inst Basic Med Sci, Neurosci Ctr, Dept Human Anat Histol & Embryol, Beijing, Peoples R China 4.Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Comp Technol, Beijing, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai, Peoples R China 7.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Li, Hongyi,Yin, Yajun,Yang, Chongqing,et al. Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body[J]. CELL PROLIFERATION,2020:8.
APA	Li, Hongyi.,Yin, Yajun.,Yang, Chongqing.,Chen, Min.,Wang, Fang.,...&Hu, Jun.(2020).Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body.CELL PROLIFERATION,8.
MLA	Li, Hongyi,et al."Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body".CELL PROLIFERATION (2020):8.