CMTTdb: the cancer molecular targeted therapy database

doi:10.21037/atm.2019.10.23

	CMTTdb: the cancer molecular targeted therapy database
	Bai, Xue 1,2,3; Yang, Xiaobo 1,2; Wu, Liangcai 1,2,4,5; Zuo, Bangyou 1; Lin, Jianzhen 1; Wang, Shanshan 1; Bian, Jin 1; Sang, Xinting 1; He, Yungang 2; Yang, Zhen 1,2; Zhao, Haitao 1
	2019-11-01
发表期刊	ANNALS OF TRANSLATIONAL MEDICINE
ISSN	2305-5839
卷号	7 期号:22 页码:7
摘要	Background: The cancer molecular targeted therapy has achieved unprecedented progress in the past decade and is thought to be the most promising direction for cancer treatment in future. As the fast growing of the clinical trials of targeted anticancer agents for different cancer types, it is critical to collect and integrate such information to guide clinical practice. Methods: We constructed the Cancer Molecular Targeted Therapy database (CMTTdb) to store and retrieve molecular targeted therapy data about randomized clinical trials (RCTs) of targeted agents and also accompanied targets, biomarkers, targeted cancer subtypes, etc. Results: Different with some existing resources, CMTTdb particularly focuses on clinical application of the trails. Design of the trails, such as treatment modalities (monotherapy or combination with other therapies), as well as results on clinical efficacy parameters, adverse events are also collected. In this current version, CMTTdb contains data for 1,088 clinical trials which cover 165 agents, 80 targets, 15 cancer types (95 molecular subtypes and 56 histological or cytological subtypes) from public literatures. This database is freely available at http://www.biosino.org/CMTTdb. A user-friendly web interface was designed so that these data can be easily retrieved. Conclusions: CMTTdb will be a valuable source for providing access to information of clinical trials on the rapidly growing number of novel targeted agent and be useful in guiding oncologists for the optimization of the therapy strategy for cancer treatment.
关键词	Molecular-targeted therapy clinical trial cancer database
DOI	10.21037/atm.2019.10.23
收录类别	SCI
语种	英语
资助项目	International Science and Technology Cooperation Projects[2016YFE0107100] ; International Science and Technology Cooperation Projects[2015DFA30650] ; CAMS Innovation Fund for Medical Science (CIFMS)[2017-I2M-4-003] ; CAMS Innovation Fund for Medical Science (CIFMS)[2018-I2M-3-001] ; Beijing Natural Science Foundation[L172055] ; Beijing Natural Science Foundation[7192158] ; Fundamental Research Funds for the Central Universities[3332018032] ; National Ten-thousand Talent Program of the Chinese Academy of Sciences[2016252] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2016252] ; Youth foundation of the national natural science foundation of China[81902620] ; Youth foundation of the national natural science foundation of China[81902353]
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS类目	Oncology ; Medicine, Research & Experimental
WOS记录号	WOS:000500459400057
出版者	AME PUBL CO
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/14963
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Yang, Zhen; Zhao, Haitao
作者单位	1.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Liver Surg, Beijing 100730, Peoples R China 2.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China 3.Northern Med Univ, Clin Coll 1, Nanfang Hosp, Dept Radiol, Guangzhou 510515, Guangdong, Peoples R China 4.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China 5.Fudan Univ, Obstet & Gynecol Hosp, Dept Obstet & Gynecol, Shanghai 200090, Peoples R China
推荐引用方式 GB/T 7714	Bai, Xue,Yang, Xiaobo,Wu, Liangcai,et al. CMTTdb: the cancer molecular targeted therapy database[J]. ANNALS OF TRANSLATIONAL MEDICINE,2019,7(22):7.
APA	Bai, Xue.,Yang, Xiaobo.,Wu, Liangcai.,Zuo, Bangyou.,Lin, Jianzhen.,...&Zhao, Haitao.(2019).CMTTdb: the cancer molecular targeted therapy database.ANNALS OF TRANSLATIONAL MEDICINE,7(22),7.
MLA	Bai, Xue,et al."CMTTdb: the cancer molecular targeted therapy database".ANNALS OF TRANSLATIONAL MEDICINE 7.22(2019):7.