Analysis of correlations between protein complex and protein-protein interaction and mRNA expression

doi:10.1360/03wc0123

	Analysis of correlations between protein complex and protein-protein interaction and mRNA expression
	Cai, L ; Xue, H ; Lu, HC ; Zhao, Y ; Zhu, XP ; Bu, DB ; Ling, LJ ; Chen, RS
	2003-10-01
发表期刊	CHINESE SCIENCE BULLETIN
ISSN	1001-6538
卷号	48 期号:20 页码:2226-2230
摘要	Protein-protein interaction is a physical interaction of two proteins in living cells. In budding yeast Saccharomyces cerevisiae, large-scale protein-protein interaction data have been obtained through high-throughput yeast two-hybrid systems (Y2H) and protein complex purification techniques based on mass-spectrometry. Here, we collect 11855 interactions between total 2617 proteins. Through seriate genome-wide mRNA expression data, similarity between two genes could be measured. Protein complex data can also be obtained publicly and can be translated to pair relationship that any two proteins can only exist in the same complex or not. Analysis of protein complex data, protein-protein interaction data and mRNA expression data can elucidate correlations between them. The results show that proteins that have interactions or similar expression patterns have a higher possibility to be in the same protein complex than randomized selected proteins, and proteins which have interactions and similar expression patterns are even more possible to exist in the same protein complex. The work indicates that comprehensive integration and analysis of public large-scale bioinformatical data, such as protein complex data, protein-protein interaction data and mRNA expression data, may help to uncover their relationships and common biological information underlying these data. The strategies described here may help to integrate and analyze other functional genomic and proteomic data, such as gene expression profiling, protein-localization mapping and large-scale phenotypic data, both in yeast and in other organisms.
关键词	protein-protein interaction mRNA expression protein complex correlation yeast
DOI	10.1360/03wc0123
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000186305600016
出版者	SCIENCE CHINA PRESS
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/13749
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chen, RS
作者单位	1.Chinese Acad Sci, IIP Lab, Inst Comp Technol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Cai, L,Xue, H,Lu, HC,et al. Analysis of correlations between protein complex and protein-protein interaction and mRNA expression[J]. CHINESE SCIENCE BULLETIN,2003,48(20):2226-2230.
APA	Cai, L.,Xue, H.,Lu, HC.,Zhao, Y.,Zhu, XP.,...&Chen, RS.(2003).Analysis of correlations between protein complex and protein-protein interaction and mRNA expression.CHINESE SCIENCE BULLETIN,48(20),2226-2230.
MLA	Cai, L,et al."Analysis of correlations between protein complex and protein-protein interaction and mRNA expression".CHINESE SCIENCE BULLETIN 48.20(2003):2226-2230.