SiRNA designs to the crucial proteins of SARS coronavirus

	SiRNA designs to the crucial proteins of SARS coronavirus
	Zhang, Y ; Xu, JY ; Deng, W ; Zhang, N ; Cai, L ; Zhao, Y ; Bu, D ; Chen, RS
	2003-06-01
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
卷号	30 期号:3 页码:335-338
摘要	RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene silencing in animals and plants, initiated by double-stranded RNA (dsRNA) that is homologous in sequence to the silenced gene. In mammal cells, small interfering RNA (siRNA) duplexes can induce RNAi potently, which may provide a new approach to the therapeutics of certain diseases. Focusing on the five genes which coding five crucial proteins of SARS coronavirus(SARS-CoV) respectively, 348 siRNA candidate targets were obtained following bioinformatic methods. In theory, potent siRNA duplexes specifically suppress expression of their corresponding SARS-CoV target gene, while have no influence on the normal expression of human gene. It would lay a foundation for the further experimental researches on the siRNA-like drug design for the SARS-CoV.
关键词	SARS coronavirus (SARS-CoV) RNA interference (RNAi) small interfering RNA (siRNA) bioinformatics
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000183733500002
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/13677
专题	中国科学院计算技术研究所期刊论文_英文
作者单位	1.Chinese Acad Sci, Bioinformat Lab, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Bioinformat Res Grp, Key Lab Intelligent Informat Proc, Comp Technol Inst, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Y,Xu, JY,Deng, W,et al. SiRNA designs to the crucial proteins of SARS coronavirus[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2003,30(3):335-338.
APA	Zhang, Y.,Xu, JY.,Deng, W.,Zhang, N.,Cai, L.,...&Chen, RS.(2003).SiRNA designs to the crucial proteins of SARS coronavirus.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,30(3),335-338.
MLA	Zhang, Y,et al."SiRNA designs to the crucial proteins of SARS coronavirus".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 30.3(2003):335-338.