Identifying Schistosoma japonicum Excretory/Secretory Proteins and Their Interactions with Host Immune System

doi:10.1371/journal.pone.0023786

	Identifying Schistosoma japonicum Excretory/Secretory Proteins and Their Interactions with Host Immune System
	Liao, Qi 1,2,3; Yuan, Xiongying 3; Xiao, Hui 3; Liu, Changning 3; Lv, Zhiyue 1,2; Zhao, Yi 3; Wu, Zhongdao 1,2
	2011-08-24
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	6 期号:8 页码:11
摘要	Schistosoma japonicum is a major infectious agent of schistosomiasis. It has been reported that large number of proteins excreted and secreted by S. japonicum during its life cycle are important for its infection and survival in definitive hosts. These proteins can be used as ideal candidates for vaccines or drug targets. In this work, we analyzed the protein sequences of S. japonicum and found that compared with other proteins in S. japonicum, excretory/secretory (ES) proteins are generally longer, more likely to be stable and enzyme, more likely to contain immune-related binding peptides and more likely to be involved in regulation and metabolism processes. Based on the sequence difference between ES and non-ES proteins, we trained a support vector machine (SVM) with much higher accuracy than existing approaches. Using this SVM, we identified 191 new ES proteins in S. japonicum, and further predicted 7 potential interactions between these ES proteins and human immune proteins. Our results are useful to understand the pathogenesis of schistosomiasis and can serve as a new resource for vaccine or drug targets discovery for anti-schistosome.
DOI	10.1371/journal.pone.0023786
收录类别	SCI
语种	英语
资助项目	National '973' project of China[2007CB513102] ; National Science Foundation of China[30972574] ; National Science Foundation of China[30771888] ; National Science Foundation of China[81000743] ; National Science Foundation of China[30800966]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000295832000060
出版者	PUBLIC LIBRARY SCIENCE
引用统计	被引频次：33[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/12976
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Liao, Qi
作者单位	1.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Parasitol, Guangzhou 510275, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Minist Educ, Key Lab Trop Dis Control, Guangzhou 510275, Guangdong, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Bioinformat Res Grp, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liao, Qi,Yuan, Xiongying,Xiao, Hui,et al. Identifying Schistosoma japonicum Excretory/Secretory Proteins and Their Interactions with Host Immune System[J]. PLOS ONE,2011,6(8):11.
APA	Liao, Qi.,Yuan, Xiongying.,Xiao, Hui.,Liu, Changning.,Lv, Zhiyue.,...&Wu, Zhongdao.(2011).Identifying Schistosoma japonicum Excretory/Secretory Proteins and Their Interactions with Host Immune System.PLOS ONE,6(8),11.
MLA	Liao, Qi,et al."Identifying Schistosoma japonicum Excretory/Secretory Proteins and Their Interactions with Host Immune System".PLOS ONE 6.8(2011):11.