Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network

doi:10.1093/nar/gkq1348

	Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network
	Liao, Qi 1,2,3; Liu, Changning 1; Yuan, Xiongying 1,4; Kang, Shuli 1; Miao, Ruoyu 5; Xiao, Hui 1; Zhao, Guoguang 1,4; Luo, Haitao 1; Bu, Dechao 1,4; Zhao, Haitao 5; Skogerbo, Geir 6,7; Wu, Zhongdao 2,3; Zhao, Yi 1
	2011-05-01
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	39 期号:9 页码:3864-3878
摘要	Although accumulating evidence has provided insight into the various functions of long-non-coding RNAs (lncRNAs), the exact functions of the majority of such transcripts are still unknown. Here, we report the first computational annotation of lncRNA functions based on public microarray expression profiles. A coding-non-coding gene co-expression (CNC) network was constructed from re-annotated Affymetrix Mouse Genome Array data. Probable functions for altogether 340 lncRNAs were predicted based on topological or other network characteristics, such as module sharing, association with network hubs and combinations of co-expression and genomic adjacency. The functions annotated to the lncRNAs mainly involve organ or tissue development (e.g. neuron, eye and muscle development), cellular transport (e.g. neuronal transport and sodium ion, acid or lipid transport) or metabolic processes (e.g. involving macromolecules, phosphocreatine and tyrosine).
DOI	10.1093/nar/gkq1348
收录类别	SCI
语种	英语
资助项目	National High Technology Research and Development of China[2008AA02Z306] ; Chinese Academy of Sciences[KSCX2-EW-R-01] ; National Program on Key Basic Research Project[2010CB530004] ; National Natural Science Foundation of China[31071137] ; National Natural Science Foundation of China[30771888] ; National Natural Science Foundation of China[30972574]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000290589500037
出版者	OXFORD UNIV PRESS
引用统计	被引频次：464[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/12675
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhao, Yi
作者单位	1.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Lab, Bioinformat Res Grp,Key Lab Intelligent Informat, Beijing, Peoples R China 2.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Parasitol, Guangzhou 510275, Guangdong, Peoples R China 3.Sun Yat Sen Univ, Minist Educ, Key Lab Trop Dis Control, Guangzhou 510275, Guangdong, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 5.Chinese Acad Sci, Peking Union Med Coll Hosp, Dept Liver Surg, CAMS & PUMC, Beijing, Peoples R China 6.Chinese Acad Sci, Bioinformat Lab, Beijing, Peoples R China 7.Chinese Acad Sci, Natl Lab Biomacromol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liao, Qi,Liu, Changning,Yuan, Xiongying,et al. Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network[J]. NUCLEIC ACIDS RESEARCH,2011,39(9):3864-3878.
APA	Liao, Qi.,Liu, Changning.,Yuan, Xiongying.,Kang, Shuli.,Miao, Ruoyu.,...&Zhao, Yi.(2011).Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network.NUCLEIC ACIDS RESEARCH,39(9),3864-3878.
MLA	Liao, Qi,et al."Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network".NUCLEIC ACIDS RESEARCH 39.9(2011):3864-3878.