A framework to refine particle clusters produced by EMAN

doi:10.1093/bioinformatics/btp219

	A framework to refine particle clusters produced by EMAN
	Fan, Liya 1,2; Zhang, Fa 1; Wang, Gongming 1,2; Liu, Zhiyong 1
	2009-06-15
发表期刊	BIOINFORMATICS
ISSN	1367-4803
卷号	25 期号:12 页码:I276-I280
摘要	Motivation: EMAN is one of the most popular software packages for single particle reconstruction. But the particle clusters produced during its model re. ning stage are of low qualities. We attempt to re. ne the particle clusters by more accurately determining orientations of particles, and thereby achieving higher resolutions of consequent 3D structures. Results: A particle reclustering framework (PRF) is introduced, which consists of three components. Each of them is responsible for one of the basic tasks of PRF: normalization, threshold determination and reclustering. Our implementation is also described and proved to meet the constraints proposed by PRF. Experiments revealed that our implementation improved resolutions of consequent structures for most cases, but only a little extra execution time was incurred. Therefore, it is practical to incorporate PRF in EMAN to improve qualities of generated 3D structures.
DOI	10.1093/bioinformatics/btp219
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics
WOS类目	Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Statistics & Probability
WOS记录号	WOS:000266498300035
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/11726
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhang, Fa
作者单位	1.Chinese Acad Sci, Inst Comp Technol, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Fan, Liya,Zhang, Fa,Wang, Gongming,et al. A framework to refine particle clusters produced by EMAN[J]. BIOINFORMATICS,2009,25(12):I276-I280.
APA	Fan, Liya,Zhang, Fa,Wang, Gongming,&Liu, Zhiyong.(2009).A framework to refine particle clusters produced by EMAN.BIOINFORMATICS,25(12),I276-I280.
MLA	Fan, Liya,et al."A framework to refine particle clusters produced by EMAN".BIOINFORMATICS 25.12(2009):I276-I280.